Impact of tuberculosis treatment length and adherence under different transmission intensities

S. T. R. Pinho, Paula Cristiana Costa Garcia da Silva Patricio Rodrigues, R. F. S. Andrade, H Serra, J. S. Lopes, M. G. M. Gomes

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
15 Downloads (Pure)

Abstract

Tuberculosis(TB) is a leading cause of human mortality due to infectious disease.Treatmentdefault is a relevant factor which reduces therapeutic success and increases the risk of resistant TB. In this work we analyze the relation betweentreatmentdefault andtreatmentlengthalong with its consequence on the disease spreading. We use a stylized model structure to explore, systematically, the effects of varyingtreatmentduration and compliance. We find that shorteningtreatmentalone may not reduce TB prevalence, especially in regions wheretransmissionintensity is high, indicating the necessity of complementing this action with increased compliance. A family of default functions relating the proportion of defaulters to thetreatmentlengthis considered and adjusted to a particular dataset. We find that the epidemiological benefits of shortertreatmentregimens are tightly associated with increases intreatmentcompliance and depend on the epidemiological background.
Original languageEnglish
Pages (from-to)68-77
JournalTheoretical Population Biology
Volume104
DOIs
Publication statusPublished - 1 Sep 2015

Keywords

  • Default
  • Mathematical model
  • Reinfection
  • Treatment;
  • Tuberculosis

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