Impact of extraction parameters and concentration by nanofiltration on the recovery of phenolic compounds from Cynara cardunculus var. altilis

Assessment of antioxidant activity

Teresa Brás, Olinda Guerreiro, Maria F. Duarte, Luísa A. Neves

Research output: Contribution to journalArticle

13 Citations (Scopus)


Cynara cardunculus var. altilis has been reported to be an excellent source of phenolic compounds. Being extraction methodology a crucial step for final extract properties, batch solid-liquid extraction, the most commonly used method, was studied and parameters such as solvent concentration, stirring rate and sequential extraction were tested in order to understand their impact on: kinetic rate, total phenolic compounds concentration and extracts antioxidant activity. Profile of phenolic extraction of C. cardunculus appeared as a first order steady-state, being the kinetic rate influenced by solvent concentration, as well as by a lipophilic fraction removal, within a sequential extraction. Based on the high kinetic rate, and antioxidant activity, sequential extraction was therefore chosen as the best methodology for C. cardunculus phenolic compounds extraction. After extraction evaluation study, nanofiltration was used to concentrate phenolic extracts, having the results shown an increase on antioxidant activity, and on total phenolic compounds concentration, as well on chlorogenic acid levels.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalIndustrial Crops and Products
Publication statusPublished - 1 May 2015



  • Antioxidant activity
  • C. cardunculus var. altilis
  • Chlorogenic acid
  • Nanofiltration
  • Phenolic compounds extraction

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