Impact of chirality on peculiar ibuprofen molecular dynamics: Hydrogen bonding organization and: Syn vs. anti carboxylic group conformations

Martin Thierry Ottou Abe, María Teresa Viciosa, Natália T. Correia, Frédéric Affouard

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Studies of the impact of chirality on amorphous states are scarce. Here, we present combined dielectric relaxation spectroscopy (DRS) experiments and molecular dynamics (MD) simulation investigations of homochiral and racemic ibuprofen in the liquid, undercooled liquid and glassy states. The influence of chirality is particularly investigated on the syn and anti conformations of the -COOH moiety of the ibuprofen molecule and its link to the peculiar Debye-like dynamical process detected in this compound. Most of the studied properties are found to be nearly identical in the homochiral and racemic systems. But the polarity and intensity of the Debye-like process are clearly found to be more intense in the racemic mixture than in the enantiomerically pure ibuprofen. The difference is explained by the higher population of the anti conformation (with the higher dipole moment) and the lower population of hydrogen bonded cyclic dimers that can be transiently formed in the racemic mixture.

Original languageEnglish
Pages (from-to)29528-29538
Number of pages11
JournalPhysical Chemistry Chemical Physics
Volume20
Issue number46
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • ibuprofen
  • molecular dynamics
  • chemistry
  • conformation
  • hydrogen bond
  • impedance spectroscopy

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