Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial

Cláudia Marques, Liliana Dinis, Inês Barreiros Mota, Juliana Morais, Shámila Ismael, José B Pereira-Leal, Joana Cardoso, Pedro Ribeiro, Helena Beato, Mafalda Resende, Christophe Espírito Santo, Ana Paula Cortez, André Rosário, Diogo Pestana, Diana Teixeira, Ana Faria, Conceição Calhau

Research output: Contribution to journalArticlepeer-review

Abstract

Gut microbiota modulation might constitute a mechanism mediating the effects of beer on health. In this randomized, double-blinded, two-arm parallel trial, 22 healthy men were recruited to drink 330 mL of nonalcoholic beer (0.0% v/v) or alcoholic beer (5.2% v/v) daily during a 4-week follow-up period. Blood and faecal samples were collected before and after the intervention period. Gut microbiota was analyzed by 16S rRNA gene sequencing. Drinking nonalcoholic or alcoholic beer daily for 4 weeks did not increase body weight and body fat mass and did not changed significantly serum cardiometabolic biomarkers. Nonalcoholic and alcoholic beer increased gut microbiota diversity which has been associated with positive health outcomes and tended to increase faecal alkaline phosphatase activity, a marker of intestinal barrier function. These results suggest the effects of beer on gut microbiota modulation are independent of alcohol and may be mediated by beer polyphenols.

Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
DOIs
Publication statusE-pub ahead of print - 15 Jun 2022

Keywords

  • alcohol
  • beer
  • gut microbiota
  • nonalcoholic beer
  • polyphenols

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