TY - JOUR
T1 - Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers
AU - Machado Caetano, J. A.
AU - Paramés, M. T.
AU - Babo, M. J.
AU - Santos, A.
AU - Bandeira Ferreira, A.
AU - Freitas, A. A.
AU - Clemente Coelho, M. R.
AU - Matthioli Mateus, A.
PY - 1986
Y1 - 1986
N2 - Investigation of oral administration of Saccharomyces boulardii in healthy volunteers demonstrates several cellular and humoral changes in peripheral blood. Among its effects are the increase of erythrocytes, leucocytes, polymorphs, neutrophils, complement components C3, C5, C3d, serum anticomplementary activity and leucocyte chemokinesis, specially when autologous serum and antigen have been added to the culture medium and decrease of complement haemolytic activity (CH50, classic and alternative pathways). We have also demonstrated that in vitro S. boulardii was able to activate complement directly, to fix C3b to its surface and that its phagocytosis by mononuclear cells was complement-dependent. The overall changes in serum proteins suggested changes of acute phase proteins typical of an inflammatory process. Furthermore S. boulardii had no mitogenic response of lymphocyte populations. Our results demonstrated that S. boulardii activates the reticuloendothelial system and complement system and suggest that S. boulardii merits therapeutic trial in a variety of clinical situations.
AB - Investigation of oral administration of Saccharomyces boulardii in healthy volunteers demonstrates several cellular and humoral changes in peripheral blood. Among its effects are the increase of erythrocytes, leucocytes, polymorphs, neutrophils, complement components C3, C5, C3d, serum anticomplementary activity and leucocyte chemokinesis, specially when autologous serum and antigen have been added to the culture medium and decrease of complement haemolytic activity (CH50, classic and alternative pathways). We have also demonstrated that in vitro S. boulardii was able to activate complement directly, to fix C3b to its surface and that its phagocytosis by mononuclear cells was complement-dependent. The overall changes in serum proteins suggested changes of acute phase proteins typical of an inflammatory process. Furthermore S. boulardii had no mitogenic response of lymphocyte populations. Our results demonstrated that S. boulardii activates the reticuloendothelial system and complement system and suggest that S. boulardii merits therapeutic trial in a variety of clinical situations.
UR - http://www.scopus.com/inward/record.url?scp=0022654468&partnerID=8YFLogxK
U2 - 10.1016/0192-0561(86)90106-2
DO - 10.1016/0192-0561(86)90106-2
M3 - Article
C2 - 3733298
AN - SCOPUS:0022654468
SN - 0192-0561
VL - 8
SP - 245
EP - 259
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
IS - 3
ER -
