Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers

J. A. Machado Caetano, M. T. Paramés, M. J. Babo, A. Santos, A. Bandeira Ferreira, A. A. Freitas, M. R. Clemente Coelho, A. Matthioli Mateus

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Investigation of oral administration of Saccharomyces boulardii in healthy volunteers demonstrates several cellular and humoral changes in peripheral blood. Among its effects are the increase of erythrocytes, leucocytes, polymorphs, neutrophils, complement components C3, C5, C3d, serum anticomplementary activity and leucocyte chemokinesis, specially when autologous serum and antigen have been added to the culture medium and decrease of complement haemolytic activity (CH50, classic and alternative pathways). We have also demonstrated that in vitro S. boulardii was able to activate complement directly, to fix C3b to its surface and that its phagocytosis by mononuclear cells was complement-dependent. The overall changes in serum proteins suggested changes of acute phase proteins typical of an inflammatory process. Furthermore S. boulardii had no mitogenic response of lymphocyte populations. Our results demonstrated that S. boulardii activates the reticuloendothelial system and complement system and suggest that S. boulardii merits therapeutic trial in a variety of clinical situations.

Original languageEnglish
Pages (from-to)245-259
Number of pages15
JournalInternational Journal of Immunopharmacology
Volume8
Issue number3
DOIs
Publication statusPublished - 1986

Fingerprint Dive into the research topics of 'Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers'. Together they form a unique fingerprint.

  • Cite this

    Machado Caetano, J. A., Paramés, M. T., Babo, M. J., Santos, A., Bandeira Ferreira, A., Freitas, A. A., ... Matthioli Mateus, A. (1986). Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers. International Journal of Immunopharmacology, 8(3), 245-259. https://doi.org/10.1016/0192-0561(86)90106-2