TY - JOUR
T1 - Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
AU - Isidro, Joana
AU - Santos, Andrea
AU - Nunes, Alexandra
AU - Borges, Vitor
AU - Silva, Catarina
AU - Vieira, Luis
AU - Mendes, Aristides L.
AU - Serrano, Monica
AU - Henriques, Adriano O.
AU - Gomes, Joao Paulo
AU - Oleastro, Monica
PY - 2018/4
Y1 - 2018/4
N2 - We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
AB - We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
UR - http://www.scopus.com/record/display.uri?eid=2-s2.0-85044224414&origin=resultslist&sort=plf-f&src=s&st1
U2 - 10.3201/eid2404.170095
DO - 10.3201/eid2404.170095
M3 - Article
SN - 1080-6040
VL - 24
SP - 741
EP - 745
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 4
ER -