Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

Joana Isidro, Andrea Santos, Alexandra Nunes, Vitor Borges, Catarina Silva, Luis Vieira, Aristides L. Mendes, Monica Serrano, Adriano O. Henriques, Joao Paulo Gomes, Monica Oleastro

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
1 Downloads (Pure)


We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalEmerging Infectious Diseases
Issue number4
Publication statusPublished - Apr 2018

Cite this