Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone.

SS Costa; E, Ntokou; A, Martins; Miguel Viveiros Bettencourt; S Pouranas; Isabel Maria dos Santos Leitão Couto; Leonard Amaral

doi:10.1016/j.ijantimicag.2010.08.006

Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone.

SS Costa, E, Ntokou , A, Martins , Miguel Viveiros Bettencourt, S Pouranas, Isabel Maria dos Santos Leitão Couto, Leonard Amaral

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial bacterium for which prevention and control measures consist mainly of the application of biocides with antiseptic and disinfectant activity. In this study, we demonstrated the presence of the plasmid-located efflux pump gene qacA in MRSA strain HPV107, a clinical isolate representative of the MRSA Iberian clone. The existence of efflux activity in strain HPV107 due to the QacA pump was also established and this QacA efflux activity was linked with a phenotype of reduced susceptibility towards several biocide compounds. No association could be made with antibiotic resistance. This work emphasises the potential of QacA pump activity in the maintenance and dissemination of important MRSA strains in the hospital setting and, increasingly, in the community.

Original language	English
Pages (from-to)	557-61
Journal	International Journal Of Antimicrobial Agents
Volume	36
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2010.08.006
Publication status	Published - 1 Jan 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijantimicag.2010.08.006

Cite this

Costa, SS., Ntokou , E., Martins , A., Bettencourt, M. V., Pouranas, S., Couto, I. M. D. S. L., & Amaral, L. (2010). Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone. International Journal Of Antimicrobial Agents, 36(6), 557-61. https://doi.org/10.1016/j.ijantimicag.2010.08.006

@article{3b723a33fb4e40eeb1b8dab03bbc7b78,

title = "Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone.",

abstract = "Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial bacterium for which prevention and control measures consist mainly of the application of biocides with antiseptic and disinfectant activity. In this study, we demonstrated the presence of the plasmid-located efflux pump gene qacA in MRSA strain HPV107, a clinical isolate representative of the MRSA Iberian clone. The existence of efflux activity in strain HPV107 due to the QacA pump was also established and this QacA efflux activity was linked with a phenotype of reduced susceptibility towards several biocide compounds. No association could be made with antibiotic resistance. This work emphasises the potential of QacA pump activity in the maintenance and dissemination of important MRSA strains in the hospital setting and, increasingly, in the community.",

author = "SS Costa and E, Ntokou and A, Martins and Bettencourt, {Miguel Viveiros} and S Pouranas and Couto, {Isabel Maria dos Santos Leit{\~a}o} and Leonard Amaral",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/j.ijantimicag.2010.08.006",

language = "English",

volume = "36",

pages = "557--61",

journal = "International Journal Of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier",

number = "6",

}

Costa, SS, Ntokou , E, Martins , A , Bettencourt, MV, Pouranas, S, Couto, IMDSL & Amaral, L 2010, 'Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone.', International Journal Of Antimicrobial Agents, vol. 36, no. 6, pp. 557-61. https://doi.org/10.1016/j.ijantimicag.2010.08.006

Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone. / Costa, SS; Ntokou , E,; Martins , A, et al.
In: International Journal Of Antimicrobial Agents, Vol. 36, No. 6, 01.01.2010, p. 557-61.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone.

AU - Costa, SS

AU - Ntokou , E,

AU - Martins , A,

AU - Bettencourt, Miguel Viveiros

AU - Pouranas, S

AU - Couto, Isabel Maria dos Santos Leitão

AU - Amaral, Leonard

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial bacterium for which prevention and control measures consist mainly of the application of biocides with antiseptic and disinfectant activity. In this study, we demonstrated the presence of the plasmid-located efflux pump gene qacA in MRSA strain HPV107, a clinical isolate representative of the MRSA Iberian clone. The existence of efflux activity in strain HPV107 due to the QacA pump was also established and this QacA efflux activity was linked with a phenotype of reduced susceptibility towards several biocide compounds. No association could be made with antibiotic resistance. This work emphasises the potential of QacA pump activity in the maintenance and dissemination of important MRSA strains in the hospital setting and, increasingly, in the community.

AB - Meticillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial bacterium for which prevention and control measures consist mainly of the application of biocides with antiseptic and disinfectant activity. In this study, we demonstrated the presence of the plasmid-located efflux pump gene qacA in MRSA strain HPV107, a clinical isolate representative of the MRSA Iberian clone. The existence of efflux activity in strain HPV107 due to the QacA pump was also established and this QacA efflux activity was linked with a phenotype of reduced susceptibility towards several biocide compounds. No association could be made with antibiotic resistance. This work emphasises the potential of QacA pump activity in the maintenance and dissemination of important MRSA strains in the hospital setting and, increasingly, in the community.

U2 - 10.1016/j.ijantimicag.2010.08.006

DO - 10.1016/j.ijantimicag.2010.08.006

M3 - Article

C2 - 20889313

SN - 0924-8579

VL - 36

SP - 557

EP - 561

JO - International Journal Of Antimicrobial Agents

JF - International Journal Of Antimicrobial Agents

IS - 6

ER -

Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this