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Abstract

In recent years many studies on cherries have revealed that they are rich sources of bioactive compounds with potential human health benefits. In this work, we evaluated the antioxidant activity and antiproliferative effect in human cancer cells of nine sweet cherries, including two traditional cultivars from Portugal (Saco and Morangao). Results obtained in biological assays, together with the phenolic composition of cherries, were submitted to principal component analysis (PCA) which allowed samples to be grouped in terms of their bioactivity. Saco cherry and two exotic cultivars (Ulster and Lapin) proved to have higher contents of phenolic compounds, highest antioxidant activity and were the most effective in inhibiting human cancer cells derived from colon (HT29) and stomach (MKN45). Correlation of the data obtained showed that anthocyanins were the major contributors to the antioxidant capacity and antiproliferative effect of cherries. Additionally, hydroxycinnamic acids (neochlorogenic acid, chlorogenic acid and p-coumaroylquinic acid), flavan-3-ols (catechin and epicatechin) and flavonols (rutin and quercetin-3-glucoside) also play important roles in protection against oxidative stress.
Original languageEnglish
Pages (from-to)318-325
JournalFood Chemistry
Volume125
Issue number2
DOIs
Publication statusPublished - 15 Mar 2011

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Portugal
Catechin
Antioxidants
Cells
Chlorogenic Acid
Coumaric Acids
Rutin
Flavonols
Oxidative stress
Anthocyanins
antioxidant activity
Insurance Benefits
Bioactivity
Principal Component Analysis
Biological Assay
Principal component analysis
acids
Assays
Neoplasms
coumaric acids

Cite this

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title = "Identification of bioactive response in traditional cherries from Portugal",
abstract = "In recent years many studies on cherries have revealed that they are rich sources of bioactive compounds with potential human health benefits. In this work, we evaluated the antioxidant activity and antiproliferative effect in human cancer cells of nine sweet cherries, including two traditional cultivars from Portugal (Saco and Morangao). Results obtained in biological assays, together with the phenolic composition of cherries, were submitted to principal component analysis (PCA) which allowed samples to be grouped in terms of their bioactivity. Saco cherry and two exotic cultivars (Ulster and Lapin) proved to have higher contents of phenolic compounds, highest antioxidant activity and were the most effective in inhibiting human cancer cells derived from colon (HT29) and stomach (MKN45). Correlation of the data obtained showed that anthocyanins were the major contributors to the antioxidant capacity and antiproliferative effect of cherries. Additionally, hydroxycinnamic acids (neochlorogenic acid, chlorogenic acid and p-coumaroylquinic acid), flavan-3-ols (catechin and epicatechin) and flavonols (rutin and quercetin-3-glucoside) also play important roles in protection against oxidative stress.",
keywords = "CACO-2, PRUNUS-AVIUM L., ANTIOXIDANT ACTIVITY, CAPACITY, PHENOLIC PROFILES, ANTHOCYANINS, CELL MONOLAYERS, CERASUS, FRUITS, SWEET CHERRY",
author = "A.T. Serra and Duarte, {Rui Manuel de Oliveira} and Bronze, {Maria do Ros{\'a}rio} and Duarte, {Catarina Maria}",
year = "2011",
month = "3",
day = "15",
doi = "10.1016/j.foodchem.2010.07.088",
language = "English",
volume = "125",
pages = "318--325",
journal = "Food Chemistry",
issn = "0308-8146",
publisher = "Elsevier Science B.V., Amsterdam.",
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TY - JOUR

T1 - Identification of bioactive response in traditional cherries from Portugal

AU - Serra, A.T.

AU - Duarte, Rui Manuel de Oliveira

AU - Bronze, Maria do Rosário

AU - Duarte, Catarina Maria

PY - 2011/3/15

Y1 - 2011/3/15

N2 - In recent years many studies on cherries have revealed that they are rich sources of bioactive compounds with potential human health benefits. In this work, we evaluated the antioxidant activity and antiproliferative effect in human cancer cells of nine sweet cherries, including two traditional cultivars from Portugal (Saco and Morangao). Results obtained in biological assays, together with the phenolic composition of cherries, were submitted to principal component analysis (PCA) which allowed samples to be grouped in terms of their bioactivity. Saco cherry and two exotic cultivars (Ulster and Lapin) proved to have higher contents of phenolic compounds, highest antioxidant activity and were the most effective in inhibiting human cancer cells derived from colon (HT29) and stomach (MKN45). Correlation of the data obtained showed that anthocyanins were the major contributors to the antioxidant capacity and antiproliferative effect of cherries. Additionally, hydroxycinnamic acids (neochlorogenic acid, chlorogenic acid and p-coumaroylquinic acid), flavan-3-ols (catechin and epicatechin) and flavonols (rutin and quercetin-3-glucoside) also play important roles in protection against oxidative stress.

AB - In recent years many studies on cherries have revealed that they are rich sources of bioactive compounds with potential human health benefits. In this work, we evaluated the antioxidant activity and antiproliferative effect in human cancer cells of nine sweet cherries, including two traditional cultivars from Portugal (Saco and Morangao). Results obtained in biological assays, together with the phenolic composition of cherries, were submitted to principal component analysis (PCA) which allowed samples to be grouped in terms of their bioactivity. Saco cherry and two exotic cultivars (Ulster and Lapin) proved to have higher contents of phenolic compounds, highest antioxidant activity and were the most effective in inhibiting human cancer cells derived from colon (HT29) and stomach (MKN45). Correlation of the data obtained showed that anthocyanins were the major contributors to the antioxidant capacity and antiproliferative effect of cherries. Additionally, hydroxycinnamic acids (neochlorogenic acid, chlorogenic acid and p-coumaroylquinic acid), flavan-3-ols (catechin and epicatechin) and flavonols (rutin and quercetin-3-glucoside) also play important roles in protection against oxidative stress.

KW - CACO-2

KW - PRUNUS-AVIUM L.

KW - ANTIOXIDANT ACTIVITY

KW - CAPACITY

KW - PHENOLIC PROFILES

KW - ANTHOCYANINS

KW - CELL MONOLAYERS

KW - CERASUS

KW - FRUITS

KW - SWEET CHERRY

U2 - 10.1016/j.foodchem.2010.07.088

DO - 10.1016/j.foodchem.2010.07.088

M3 - Article

VL - 125

SP - 318

EP - 325

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

IS - 2

ER -