TY - JOUR
T1 - Ibuprofen loaded PVA/chitosan membranes
T2 - A highly efficient strategy towards an improved skin wound healing
AU - Morgado, Patrícia I.
AU - Miguel, Sónia P.
AU - Correia, Ilídio J.
AU - Aguiar-Ricardo, Ana
N1 - Sem PDF.
Associate Laboratory for Green Chemistry LAQV - national funds from FCT/MEC
(UID/QUI/50006/2013)
ERDF (POCI-01-0145-FEDER-007265)
FEDER funds through the POCI - COMPETE - Operational Programme Competitiveness and Internationalisation in Axis I - Strengthening research, technological development and innovation
POCI-01-0145-FEDER-007491
National Funds by FCT - Foundation for Science and Technology (UID/Multi/00709/2013; PTDC/EQU-EQU/116097/2009; PTDC/EBB-BIO/114320/2009; SFRH/BD/80648/2011; SFRH/BD/109563/2015)
PY - 2017/3/1
Y1 - 2017/3/1
N2 - During wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclodextrins carriers were designed to customise the release profile of IBP from poly(vinyl alcohol)/chitosan (PVA/CS) dressings in order to promote a faster skin regeneration. The dressings were produced using supercritical carbon dioxide (scCO2)-assisted technique. In vitro IBP release studies showed that β-cyclodextrins allowed a controlled drug release from the hydrogels which is crucial for their application in wound management. Moreover, the in vivo assays revealed that the presence of PVA/CS membranes containing IBP-β-cyclodextrins carriers avoided scab formation and an excessive inflammation, enabling an earlier skin healing.
AB - During wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclodextrins carriers were designed to customise the release profile of IBP from poly(vinyl alcohol)/chitosan (PVA/CS) dressings in order to promote a faster skin regeneration. The dressings were produced using supercritical carbon dioxide (scCO2)-assisted technique. In vitro IBP release studies showed that β-cyclodextrins allowed a controlled drug release from the hydrogels which is crucial for their application in wound management. Moreover, the in vivo assays revealed that the presence of PVA/CS membranes containing IBP-β-cyclodextrins carriers avoided scab formation and an excessive inflammation, enabling an earlier skin healing.
KW - Composite membranes
KW - Drug delivery systems
KW - Ibuprofen
KW - In vivo assays
KW - Supercritical carbon dioxide
KW - Wound dressings
UR - http://www.scopus.com/inward/record.url?scp=85006293703&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2016.12.029
DO - 10.1016/j.carbpol.2016.12.029
M3 - Article
C2 - 28038742
AN - SCOPUS:85006293703
SN - 0144-8617
VL - 159
SP - 136
EP - 145
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -