Iatrogenic Parkinsonism: The Role of Flunarizine and Cinnarizine

Rita Miguel; Ana Sofia Aleixo  Correia; Paulo  Bugalho

doi:10.3233/JPD-140414

Iatrogenic Parkinsonism: The Role of Flunarizine and Cinnarizine

Rita Miguel, Ana Sofia Aleixo Correia, Paulo Bugalho

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

We performed a clinical report based, descriptive and retrospective study, aimed at comparing Flunarizine/Cinnarizine-induced parkinsonism (FCIP) patients and Parkinson's disease (PD) patients. The FCIP group (n = 30) presented a lower frequency of rigidity and unilateral tremor than the PD group (n = 70). All FCIP patients improved, 13 after dopaminergic treatment. FCIP patients who improved spontaneously presented lower frequency of rigidity, compared with the other FCIP subgroup and PD group. FCIP patients who did not improve spontaneously showed a clinical pattern similar to PD patients.

Original language	English
Pages (from-to)	645-649
Number of pages	5
Journal	Journal of Parkinson's Disease
Volume	4
Issue number	4
DOIs	https://doi.org/10.3233/JPD-140414
Publication status	Published - 2014

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title = "Iatrogenic Parkinsonism: The Role of Flunarizine and Cinnarizine",

abstract = "We performed a clinical report based, descriptive and retrospective study, aimed at comparing Flunarizine/Cinnarizine-induced parkinsonism (FCIP) patients and Parkinson's disease (PD) patients. The FCIP group (n = 30) presented a lower frequency of rigidity and unilateral tremor than the PD group (n = 70). All FCIP patients improved, 13 after dopaminergic treatment. FCIP patients who improved spontaneously presented lower frequency of rigidity, compared with the other FCIP subgroup and PD group. FCIP patients who did not improve spontaneously showed a clinical pattern similar to PD patients.",

keywords = "SUSCEPTIBILITY, flunarizine, nigrostriatal pathway, Calcium channel blockers, Parkinson's disease, cinnarizine, FOLLOW-UP, DISEASE, BLOCKERS, drug-induced parkinsonism",

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T1 - Iatrogenic Parkinsonism: The Role of Flunarizine and Cinnarizine

AU - Miguel, Rita

AU - Correia, Ana Sofia Aleixo

AU - Bugalho, Paulo

N1 - PMID:25125483 WOS:000345855800013

PY - 2014

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AB - We performed a clinical report based, descriptive and retrospective study, aimed at comparing Flunarizine/Cinnarizine-induced parkinsonism (FCIP) patients and Parkinson's disease (PD) patients. The FCIP group (n = 30) presented a lower frequency of rigidity and unilateral tremor than the PD group (n = 70). All FCIP patients improved, 13 after dopaminergic treatment. FCIP patients who improved spontaneously presented lower frequency of rigidity, compared with the other FCIP subgroup and PD group. FCIP patients who did not improve spontaneously showed a clinical pattern similar to PD patients.

KW - SUSCEPTIBILITY

KW - flunarizine

KW - nigrostriatal pathway

KW - Calcium channel blockers

KW - Parkinson's disease

KW - cinnarizine

KW - FOLLOW-UP

KW - DISEASE

KW - BLOCKERS

KW - drug-induced parkinsonism

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DO - 10.3233/JPD-140414

M3 - Article

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SP - 645

EP - 649

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

SN - 1877-7171

IS - 4

ER -