TY - JOUR
T1 - Hybrid hydrogel as a delivery vehicle for bioactive ions to enhance bone regeneration
AU - Oliveira, Beatriz
AU - Neves, João
AU - Malça, Cândida
AU - Campos, Sofia
AU - Sá, Joel
AU - Henriques, Marta
AU - Baptista, Ana
AU - Moura, Carla
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT#
info:eu-repo/grantAgreement/FCT/CEEC INST 2ed/CEECINST%2F00077%2F2021%2FCP2798%2FCT0001/PT#
This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Project: PAMI - ROTEIRO/0328/2013 (Nº 022158)
Publisher Copyright:
© 2023 Croatian Society for Mechanical Technologies. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Bone has a natural capacity to regenerate when slightly damaged. However, when injured at larger scale, it requires external intervention, such bone grafts, which introduces challenges, limiting their use in clinical applications. Therefore, polymeric scaffolds, namely hydrogels, appear as an interesting alternative to bone replacements. They are characterised by high water uptake and have excellent biomimetic properties. Magnesium (Mg) is a biodegradable mineral, mainly stored in bones, and possesses strong mechanical qualities closely resembling natural bone. Thus, the main objective of this work was the production of a hydrogel combining synthetic polymers to act as bone substitutes. For this purpose, polyethyleneglycol diacrylate (PEGDA) was used as the base hydrogel, in which Mg sulphate (bioactive ion) was incorporated. Mg addition led to an increase of about 19% of the compressive Young modulus, enhancing their mechanical strength and resistance to compression. Both groups, with and without Mg, presented very similar behaviours when submitted to a hydrated environment, not suffering considerable degradation during the month of the experiment.
AB - Bone has a natural capacity to regenerate when slightly damaged. However, when injured at larger scale, it requires external intervention, such bone grafts, which introduces challenges, limiting their use in clinical applications. Therefore, polymeric scaffolds, namely hydrogels, appear as an interesting alternative to bone replacements. They are characterised by high water uptake and have excellent biomimetic properties. Magnesium (Mg) is a biodegradable mineral, mainly stored in bones, and possesses strong mechanical qualities closely resembling natural bone. Thus, the main objective of this work was the production of a hydrogel combining synthetic polymers to act as bone substitutes. For this purpose, polyethyleneglycol diacrylate (PEGDA) was used as the base hydrogel, in which Mg sulphate (bioactive ion) was incorporated. Mg addition led to an increase of about 19% of the compressive Young modulus, enhancing their mechanical strength and resistance to compression. Both groups, with and without Mg, presented very similar behaviours when submitted to a hydrated environment, not suffering considerable degradation during the month of the experiment.
KW - Bone Regeneration
KW - Hydrogel
KW - Magnesium Sulphate
KW - Tissue Engineering
UR - http://www.scopus.com/inward/record.url?scp=85174859675&partnerID=8YFLogxK
M3 - Conference article
AN - SCOPUS:85174859675
SN - 1847-7917
SP - 247
EP - 252
JO - Mechanical Technology and Structural Materials
JF - Mechanical Technology and Structural Materials
IS - 60
T2 - 12th International Conference on Mechanical Technologies and Structural Materials, MTSM 2023
Y2 - 21 September 2023 through 22 September 2023
ER -