H2Me-do2pa: An attractive chelator with fast, stable and inert natBi3+ and 213Bi3+ complexation for potential α-radioimmunotherapy applications

Luís M P Lima, Maryline Beyler, Fatima Oukhatar, Patricia Le Saec, Alain Faivre-Chauvet, Carlos Platas-Iglesias, Rita Delgado, Raphaël Tripier

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference. This journal is

Original languageEnglish
Pages (from-to)12371-12374
Number of pages4
JournalChemical Communications
Volume50
Issue number82
DOIs
Publication statusPublished - 21 Oct 2014

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