hsCRP and E-Selectin as Markers of Endothelial Dysfunction in Children with Type 1 Diabetes Mellitus

Antonella Márcia Mercadante de Albuquerque DO Nascimento, Rosane Mansan Almeida, Inês Jorge Sequeira, Yanna Karla de Medeiros Nóbrega

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Abstract

Introduction: This study investigated the levels of inflammatory biomarkers in healthy children and those diagnosed with type 1 diabetes (T1DM), some of whom were affected by endothelial
dysfunction (ED), characterized by increased inflammation and reduced vasodilatation.

Methods: Thirty-one T1DM children showing no symptoms of vascular diseases and diagnosed by ultrasound techniques as ED-positive (T1DM-ED) or negative (T1DM), and 58 sex-age-matched healthy children were investigated for circulating levels of E-selectin, s-ICAM and s-VCAM, MMP-9, high-sensitivity
C-reactive protein (hsCRP), and IL-6.

Results: No differences were observed in s-ICAM, MMP-9, and IL-6 levels between case and control groups. Significantly higher levels of s-VCAM (p= 0.0001) were found in the T1DM (1359.1 ± 273 ng/mL) and T1DM-ED (1358.2 ± 112 ng/mL) groups; (control - 828.5 ± 212 ng/mL). Higher levels of E-selectin
(p = 0.001) were found in the T1DM-ED group (331.2 ± 77 ng/mL); (control - 222.2 ± 74 ng/mL). The values of hsCRP were higher (p = 0.002) in the T1DM-ED group (0.36 ± 0.2 mg/L) relative to control (0.15 ± 0.1 mg/L) and T1DM (0.19 ± 0.2 mg/L). The results suggest that E-selectin and hsCRP can be
useful markers of ED in children with T1DM.
Original languageEnglish
Number of pages8
JournalGlobal Journal of Medical Research: F Diseases
Volume18
Issue number4
Publication statusPublished - 20 Sep 2018

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Keywords

  • type 1 diabetes mellitus
  • children
  • endothelial dysfunction
  • markers
  • E-selectin
  • hsCRP

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