HR-DOSY as a new tool for the study of chemical exchange phenomena

Eurico J. Cabrita, Stefan T. A. Berger

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

DOSY NMR spectroscopy can be a fast and easy method to establish qualitatively the relative order of magnitude of the exchange rates of systems in slow exchange in chemical shift. By measuring a series of DOSY spectra of a two-site exchange system, where exchange occurs between sites with different diffusion coefficients, we show that by increasing the diffusion time among experiments it is possible to extract information about the relative exchange rates of protons with the bulk solvent and therefore infer their solvent accessibility.

Original languageEnglish
Pages (from-to)S122-S127
Number of pages6
JournalMagnetic Resonance in Chemistry
Volume40
DOIs
Publication statusPublished - 1 Dec 2002

Keywords

  • H NMR
  • BPPLED
  • Chemical exchange
  • Diffusion
  • DOSY
  • NMR

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