TY - JOUR
T1 - How microsampling is impacting pharmacokinetic and toxicokinetic studies
T2 - volumetric absorptive microsampling (VAMS)
AU - Protti, Michele
AU - Mandrioli, Roberto
AU - Santos, Hugo M.
AU - Lodeiro, Carlos
AU - Capelo-Martínez, José L.
AU - Mercolini, Laura
N1 - Funding information:
info:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0008%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT#
info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT#
The Authors M.P., R.M. and L.M. acknowledge the financial contribution from Alma Mater Studiorum - University of Bologna through Fundamental Oriented Research (RFO) funds. H.M.S., C.L. and J.L.C would like to thank the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES ([LA/P/0008/2020] DOI 10.54499/LA/P/0008/2020, [UIDP/50006/2020] DOI 10.54499/UIDP/50006/2020 and [UIDB/50006/2020] DOI 10.54499/UIDB/50006/2020), as well as the PROTEOMASS Scientific Society (Portugal) for funding support [General Funding Grant 2024–2025].The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2025 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2025/8/25
Y1 - 2025/8/25
N2 - Microsampling, using minute amounts of biological specimen, is uniquely suited for carrying out human and animal pharmacokinetic and toxicokinetic studies. Indeed, it provides important advantages over common blood-drawing procedures (e.g. increased analyte stability, simpler and cheaper storage and shipping, self-sampling possibility, reduced consumption of materials and animals) while also maintaining similar performance and result reliability. In the microsampling space, volumetric absorptive microsampling (VAMS) is currently considered one of the most important and widespread technologies, thanks to its volume accuracy capabilities, making it natively suitable for quantitative analysis. In this review, an exhaustive treatment of pharmacokinetic and toxicokinetic studies using VAMS is presented, as well as several examples of analytical methods prospectively enabling the employment of VAMS for the same purpose.
AB - Microsampling, using minute amounts of biological specimen, is uniquely suited for carrying out human and animal pharmacokinetic and toxicokinetic studies. Indeed, it provides important advantages over common blood-drawing procedures (e.g. increased analyte stability, simpler and cheaper storage and shipping, self-sampling possibility, reduced consumption of materials and animals) while also maintaining similar performance and result reliability. In the microsampling space, volumetric absorptive microsampling (VAMS) is currently considered one of the most important and widespread technologies, thanks to its volume accuracy capabilities, making it natively suitable for quantitative analysis. In this review, an exhaustive treatment of pharmacokinetic and toxicokinetic studies using VAMS is presented, as well as several examples of analytical methods prospectively enabling the employment of VAMS for the same purpose.
KW - Dried blood spots (DBS)
KW - Microsampling
KW - pharmacokinetics (PK)
KW - toxicokinetics (TK)
KW - volumetric absorptive microsampling (VAMS)
UR - https://www.scopus.com/pages/publications/105014090572
U2 - 10.1080/17576180.2025.2546782
DO - 10.1080/17576180.2025.2546782
M3 - Review article
C2 - 40851463
AN - SCOPUS:105014090572
SN - 1757-6180
VL - 17
SP - 997
EP - 1009
JO - Bioanalysis
JF - Bioanalysis
IS - 15
ER -