How inflammation impinges on NAFLD: A role for Kupffer cells

Nádia Duarte, Inês C Coelho, Rita S. Patarrão, Joana I Almeida, Carlos Penha Gonçalves, M. Paula Macedo

Research output: Contribution to journalReview article

39 Citations (Scopus)
3 Downloads (Pure)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps ofNAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.
Original languageEnglish
Pages (from-to)Online
Number of pages11
JournalBioMed Research International
Volume984578
Issue numberNA
DOIs
Publication statusPublished - 2015

Fingerprint

Kupffer Cells
Liver
Inflammation
Insulin Resistance
Liver Diseases
Obesity
Fats
Non-alcoholic Fatty Liver Disease
Insulin
Therapeutics

Keywords

  • FATTY LIVER-DISEASE
  • TOLL-LIKE RECEPTORS
  • INDUCED HEPATIC STEATOSIS
  • INSULIN-RESISTANCE
  • NONALCOHOLIC STEATOHEPATITIS
  • HEPATOCELLULAR-CARCINOMA
  • ENDOPLASMIC-RETICULUM
  • STELLATE CELLS
  • RISK-FACTORS
  • FRUCTOSE

Cite this

Duarte, Nádia ; Coelho, Inês C ; Patarrão, Rita S. ; Almeida, Joana I ; Gonçalves, Carlos Penha ; Macedo, M. Paula . / How inflammation impinges on NAFLD: A role for Kupffer cells. In: BioMed Research International. 2015 ; Vol. 984578, No. NA. pp. Online.
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abstract = "Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps ofNAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.",
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How inflammation impinges on NAFLD: A role for Kupffer cells. / Duarte, Nádia ; Coelho, Inês C; Patarrão, Rita S.; Almeida, Joana I; Gonçalves, Carlos Penha; Macedo, M. Paula .

In: BioMed Research International, Vol. 984578, No. NA, 2015, p. Online.

Research output: Contribution to journalReview article

TY - JOUR

T1 - How inflammation impinges on NAFLD: A role for Kupffer cells

AU - Duarte, Nádia

AU - Coelho, Inês C

AU - Patarrão, Rita S.

AU - Almeida, Joana I

AU - Gonçalves, Carlos Penha

AU - Macedo, M. Paula

N1 - info:eu-repo/grantAgreement/FCT/3599-PPCDT/124913/PT# info:eu-repo/grantAgreement/FCT/3599-PPCDT/124357/PT# This study was supported by Fundacao para a Ciencia e Tecnologia (FCT) Grants PTDC/DTP-EPI/0207/2012 and PTDC/BIM-MET/0486/2012 and by the Portuguese Diabetes Society (SPD).

PY - 2015

Y1 - 2015

N2 - Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps ofNAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.

AB - Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps ofNAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.

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KW - HEPATOCELLULAR-CARCINOMA

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KW - FATTY LIVER-DISEASE

KW - INDUCED HEPATIC STEATOSIS

KW - INSULIN-RESISTANCE

KW - STELLATE CELLS

KW - ENDOPLASMIC-RETICULUM

KW - NONALCOHOLIC STEATOHEPATITIS

KW - FATTY LIVER-DISEASE

KW - TOLL-LIKE RECEPTORS

KW - INDUCED HEPATIC STEATOSIS

KW - INSULIN-RESISTANCE

KW - NONALCOHOLIC STEATOHEPATITIS

KW - HEPATOCELLULAR-CARCINOMA

KW - ENDOPLASMIC-RETICULUM

KW - STELLATE CELLS

KW - RISK-FACTORS

KW - FRUCTOSE

U2 - 10.1155/2015/984578

DO - 10.1155/2015/984578

M3 - Review article

VL - 984578

SP - Online

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

IS - NA

ER -