How inflammation impinges on NAFLD: A role for Kupffer cells

Nádia Duarte, Inês C Coelho, Rita S. Patarrão, Joana I Almeida, Carlos Penha Gonçalves, M. Paula Macedo

Research output: Contribution to journalReview article

44 Citations (Scopus)
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Abstract

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps ofNAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.
Original languageEnglish
Pages (from-to)Online
Number of pages11
JournalBioMed Research International
Volume984578
Issue numberNA
DOIs
Publication statusPublished - 2015

Keywords

  • FATTY LIVER-DISEASE
  • TOLL-LIKE RECEPTORS
  • INDUCED HEPATIC STEATOSIS
  • INSULIN-RESISTANCE
  • NONALCOHOLIC STEATOHEPATITIS
  • HEPATOCELLULAR-CARCINOMA
  • ENDOPLASMIC-RETICULUM
  • STELLATE CELLS
  • RISK-FACTORS
  • FRUCTOSE

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