How genomics is contributing to the fight against artemisinin-resistant malaria parasites

Pedro Cravo; Hamilton Napolitano; Richard Culleton

doi:10.1016/j.actatropica.2015.04.007

How genomics is contributing to the fight against artemisinin-resistant malaria parasites

Pedro Cravo, Hamilton Napolitano, Richard Culleton

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

Abstract

Plasmodium falciparum, the malignant malaria parasite, has developed resistance to artemisinin, the most important and widely used antimalarial drug at present. Currently confined to Southeast Asia, the spread of resistant parasites to Africa would constitute a public health catastrophe. In this review we highlight the recent contributions of genomics to our understanding how the parasite develops resistance to artemisinin and its derivatives, and how resistant parasites may be monitored and tracked in real-time, using molecular approaches.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Acta Tropica
Volume	148
DOIs	https://doi.org/10.1016/j.actatropica.2015.04.007
Publication status	Published - Aug 2015

Keywords

Africa
Animals
Antimalarials
Artemisinins
Asia, Southeastern
Drug Resistance
Genomics
Humans
Malaria, Falciparum
Plasmodium falciparum
Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.actatropica.2015.04.007

Cite this

@article{3fe85ab099214f2b958f79eed0321d93,

title = "How genomics is contributing to the fight against artemisinin-resistant malaria parasites",

abstract = "Plasmodium falciparum, the malignant malaria parasite, has developed resistance to artemisinin, the most important and widely used antimalarial drug at present. Currently confined to Southeast Asia, the spread of resistant parasites to Africa would constitute a public health catastrophe. In this review we highlight the recent contributions of genomics to our understanding how the parasite develops resistance to artemisinin and its derivatives, and how resistant parasites may be monitored and tracked in real-time, using molecular approaches.",

keywords = "Africa, Animals, Antimalarials, Artemisinins, Asia, Southeastern, Drug Resistance, Genomics, Humans, Malaria, Falciparum, Plasmodium falciparum, Journal Article, Review",

author = "Pedro Cravo and Hamilton Napolitano and Richard Culleton",

year = "2015",

month = aug,

doi = "10.1016/j.actatropica.2015.04.007",

language = "English",

volume = "148",

pages = "1--7",

journal = "Acta Tropica",

issn = "0001-706X",

publisher = "Elsevier",

}

TY - JOUR

T1 - How genomics is contributing to the fight against artemisinin-resistant malaria parasites

AU - Cravo, Pedro

AU - Napolitano, Hamilton

AU - Culleton, Richard

PY - 2015/8

Y1 - 2015/8

N2 - Plasmodium falciparum, the malignant malaria parasite, has developed resistance to artemisinin, the most important and widely used antimalarial drug at present. Currently confined to Southeast Asia, the spread of resistant parasites to Africa would constitute a public health catastrophe. In this review we highlight the recent contributions of genomics to our understanding how the parasite develops resistance to artemisinin and its derivatives, and how resistant parasites may be monitored and tracked in real-time, using molecular approaches.

AB - Plasmodium falciparum, the malignant malaria parasite, has developed resistance to artemisinin, the most important and widely used antimalarial drug at present. Currently confined to Southeast Asia, the spread of resistant parasites to Africa would constitute a public health catastrophe. In this review we highlight the recent contributions of genomics to our understanding how the parasite develops resistance to artemisinin and its derivatives, and how resistant parasites may be monitored and tracked in real-time, using molecular approaches.

KW - Africa

KW - Animals

KW - Antimalarials

KW - Artemisinins

KW - Asia, Southeastern

KW - Drug Resistance

KW - Genomics

KW - Humans

KW - Malaria, Falciparum

KW - Plasmodium falciparum

KW - Journal Article

KW - Review

UR - https://www.sciencedirect.com/science/article/abs/pii/S0001706X15001035?via%3Dihub

U2 - 10.1016/j.actatropica.2015.04.007

DO - 10.1016/j.actatropica.2015.04.007

M3 - Review article

C2 - 25910626

SN - 0001-706X

VL - 148

SP - 1

EP - 7

JO - Acta Tropica

JF - Acta Tropica

ER -

How genomics is contributing to the fight against artemisinin-resistant malaria parasites

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this