How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

Manuel José Teixeira Carrondo, Paula Maria Alves, Nuno Carinhas, Jarka Glassey, Friedemann Hesse, Merten Otto-Wilhelm, Martina Micheletti, Thomas Noll, Rui Manuel Freitas Oliveira, Udo Reichl, Arne Staby, Ana Paula Teixeira, Henry Weichert, Carl Fredrik Mandenius

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.
Original languageEnglish
Pages (from-to)1522-1529
Number of pages8
JournalBiotechnology Journal
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Biopharmaceuticals
  • Gene therapy
  • Mammalian cells
  • Stem cells
  • Viral vectors

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