25 Citations (Scopus)

Abstract

This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.
Original languageUnknown
Pages (from-to)1522-9
JournalBiotechnology Journal
Volume7
Issue number12
DOIs
Publication statusPublished - 1 Jan 2012

Cite this

@article{2137daeb2f434703984933f4e1554dd6,
title = "How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?",
abstract = "This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.",
keywords = "Viral vectors, Stem cells, Mammalian cells, Biopharmaceuticals, Gene therapy",
author = "Oliveira, {Rui Manuel Freitas} and Carrondo, {Manuel Jos{\'e} Teixeira} and Alves, {Paula Maria} and Nuno Carinhas",
year = "2012",
month = "1",
day = "1",
doi = "10.1002/biot.201200226",
language = "Unknown",
volume = "7",
pages = "1522--9",
journal = "Biotechnology Journal",
issn = "1860-6768",
publisher = "John Wiley & Sons, Ltd",
number = "12",

}

TY - JOUR

T1 - How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

AU - Oliveira, Rui Manuel Freitas

AU - Carrondo, Manuel José Teixeira

AU - Alves, Paula Maria

AU - Carinhas, Nuno

PY - 2012/1/1

Y1 - 2012/1/1

N2 - This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.

AB - This report highlights the potential of measurement, monitoring, modeling and control (M(3) C) methodologies in animal and human cell culture technology. In particular, state-of-the-art of M(3) C technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in M(3) C are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting M(3) C research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.

KW - Viral vectors

KW - Stem cells

KW - Mammalian cells

KW - Biopharmaceuticals

KW - Gene therapy

U2 - 10.1002/biot.201200226

DO - 10.1002/biot.201200226

M3 - Article

VL - 7

SP - 1522

EP - 1529

JO - Biotechnology Journal

JF - Biotechnology Journal

SN - 1860-6768

IS - 12

ER -