Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection

A Case-Control Study

Vania Gaio, Baltazar Nunes, Pedro Pechirra, Patricia Conde, Raquel Guiomar, Carlos Matias Dias, Marta Barreto

Research output: Contribution to journalArticle

9 Citations (Scopus)
3 Downloads (Pure)

Abstract

Background

Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza.

Methods

A case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252.

Results

We selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95% CI: 0.33-1.50)). Regarding ILI Influenza A(H1N1) pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95% CI: 1.54-4.19)).

Conclusions

The IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1) pdm09.

Original languageEnglish
Article number0158181
Number of pages10
JournalPlosOne
Volume11
Issue number6
DOIs
Publication statusPublished - 28 Jun 2016

Keywords

  • A H1N1 VIRUS
  • SUSCEPTIBILITY

Cite this

@article{8cdf86dabd314ad6bbe4deecea7cdc8a,
title = "Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection: A Case-Control Study",
abstract = "BackgroundRecent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza.MethodsA case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252.ResultsWe selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95{\%} CI: 0.33-1.50)). Regarding ILI Influenza A(H1N1) pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95{\%} CI: 1.54-4.19)).ConclusionsThe IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1) pdm09.",
keywords = "A H1N1 VIRUS, SUSCEPTIBILITY",
author = "Vania Gaio and Baltazar Nunes and Pedro Pechirra and Patricia Conde and Raquel Guiomar and Dias, {Carlos Matias} and Marta Barreto",
year = "2016",
month = "6",
day = "28",
doi = "10.1371/journal.pone.0158181",
language = "English",
volume = "11",
journal = "PlosOne",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection : A Case-Control Study. / Gaio, Vania; Nunes, Baltazar; Pechirra, Pedro; Conde, Patricia; Guiomar, Raquel; Dias, Carlos Matias; Barreto, Marta.

In: PlosOne, Vol. 11, No. 6, 0158181, 28.06.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection

T2 - A Case-Control Study

AU - Gaio, Vania

AU - Nunes, Baltazar

AU - Pechirra, Pedro

AU - Conde, Patricia

AU - Guiomar, Raquel

AU - Dias, Carlos Matias

AU - Barreto, Marta

PY - 2016/6/28

Y1 - 2016/6/28

N2 - BackgroundRecent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza.MethodsA case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252.ResultsWe selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95% CI: 0.33-1.50)). Regarding ILI Influenza A(H1N1) pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95% CI: 1.54-4.19)).ConclusionsThe IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1) pdm09.

AB - BackgroundRecent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pandemic influenza.MethodsA case-control genetic association study was performed, using nasopharyngeal/oropharyngeal swabs collected during the H1N1 pandemic influenza. Laboratory diagnosis of influenza infection was performed by RT-PCR, the IFITM3 rs12252 was genotyped by RFLP and tested for association with hospitalization. Conditional logistic regression was performed to calculate the confounder-adjusted odds ratio of hospitalization associated with IFITM3 rs12252.ResultsWe selected 312 ILI cases and 624 matched non-hospitalized controls. Within ILI Influenza A(H1N1)pdm09 positive patients, no statistical significant association was found between the variant and the hospitalization risk (Adjusted OR: 0.73 (95% CI: 0.33-1.50)). Regarding ILI Influenza A(H1N1) pdm09 negative patients, CT/CC genotype carriers had a higher risk of being hospitalized than patients with TT genotype (Adjusted OR: 2.54 (95% CI: 1.54-4.19)).ConclusionsThe IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1) pdm09.

KW - A H1N1 VIRUS

KW - SUSCEPTIBILITY

U2 - 10.1371/journal.pone.0158181

DO - 10.1371/journal.pone.0158181

M3 - Article

VL - 11

JO - PlosOne

JF - PlosOne

SN - 1932-6203

IS - 6

M1 - 0158181

ER -