A homocisteinemia como factor de risco de doença cerebrovascular precoce.

Translated title of the contribution: Homocysteinemia as a risk factor in early cerebrovascular disease

R. P. Reis, J. Azinheira, H. P. Reis, M. Pereira, A. Baptista, M. Crespo, J. E. Pina, N. C. Ferreira, A. S. Luís

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Abstract

PURPOSE: To determine whether hyperhomocysteinemia represents a risk factor of early thrombotic cerebrovascular disease. METHOD: In a group of patients under 55 years of age (n = 33, 19 males) which had suffered a stroke from 3 months to 1 year before the study, defined by clinical criteria and presence of cerebral infarction confirmed by tomography, without history or predisposition to embolic disease. The patients were matched with a group of normal controls of checkup program, in terms of age, and sex. Patients and controls with a history of alcoholism, clinical or laboratory signs of renal or hepatic insufficiency or with a history of recent ingestion of Group B vitamins were excluded since these conditions would influence homocysteinemia levels. We measured the plasmatic basal homocysteinemia of patients and controls (HC) and 6 hours later a methionine overload of 0.1 g/Kg body weight (LOAD HC). RESULTS: Patients; Controls; Signific.; Age 46.0 +/- 7.7; 45.9 +/- 7.8; NS; Basal HC. 10.1 +/- 3.4; 8.5 +/- 1.7; p < 0.05; Load HC 28.0 +/- 7.6; 22.7 +/- 5.5; p < 0.01. CONCLUSION: In this study hyperhomocysteinemia appears as a risk factor for thrombotic cerebrovascular disease before the age of 55;-The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement;-A larger number of patients and controls will be necessary to establish the relative importance of homocysteinemia among other vascular risk factors in cerebrovascular disease.

Original languagePortuguese
Pages (from-to)285-289
Number of pages5
JournalActa medica portuguesa
Volume7
Issue number5
Publication statusPublished - 1 May 1994

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    Reis, R. P., Azinheira, J., Reis, H. P., Pereira, M., Baptista, A., Crespo, M., ... Luís, A. S. (1994). A homocisteinemia como factor de risco de doença cerebrovascular precoce. Acta medica portuguesa, 7(5), 285-289.