HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.

Kristof Theys; Jurgen Vercauteren; Joke Snoeck; Maurizio Zazzi; Ricardo Jorge Camacho; Carlo Torti; Eugen Schülter; Bonaventura Clotet; A Sonnerborg; A. De Luca; Zehava Grossman; Daniel Struck; Anne-mieke Vandamme; Ana Abecasis

doi:10.1128/AAC.01668-12

HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.

Kristof Theys, Jurgen Vercauteren, Joke Snoeck, Maurizio Zazzi, Ricardo Jorge Camacho, Carlo Torti, Eugen Schülter, Bonaventura Clotet, A Sonnerborg, A. De Luca, Zehava Grossman, Daniel Struck, Anne-mieke Vandamme, Ana Abecasis

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.

Original language	English
Pages (from-to)	1053-6
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01668-12
Publication status	Published - 1 Jan 2013

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Theys, K., Vercauteren, J., Snoeck, J., Zazzi, M., Camacho, R. J., Torti, C., Schülter, E., Clotet, B., Sonnerborg, A., De Luca, A., Grossman, Z., Struck, D., Vandamme, A., & Abecasis, A. (2013). HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir. Antimicrobial Agents and Chemotherapy, 57(2), 1053-6. https://doi.org/10.1128/AAC.01668-12

Theys, Kristof ; Vercauteren, Jurgen ; Snoeck, Joke ; Zazzi, Maurizio ; Camacho, Ricardo Jorge ; Torti, Carlo ; Schülter, Eugen ; Clotet, Bonaventura ; Sonnerborg, A ; De Luca, A. ; Grossman, Zehava ; Struck, Daniel ; Vandamme, Anne-mieke ; Abecasis, Ana. / HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 2. pp. 1053-6.

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title = "HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.",

abstract = "Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.",

author = "Kristof Theys and Jurgen Vercauteren and Joke Snoeck and Maurizio Zazzi and Camacho, {Ricardo Jorge} and Carlo Torti and Eugen Sch{\"u}lter and Bonaventura Clotet and A Sonnerborg and {De Luca}, A. and Zehava Grossman and Daniel Struck and Anne-mieke Vandamme and Ana Abecasis",

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Theys, K, Vercauteren, J, Snoeck, J, Zazzi, M, Camacho, RJ, Torti, C, Schülter, E, Clotet, B, Sonnerborg, A, De Luca, A, Grossman, Z, Struck, D, Vandamme, A & Abecasis, A 2013, 'HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.', Antimicrobial Agents and Chemotherapy, vol. 57, no. 2, pp. 1053-6. https://doi.org/10.1128/AAC.01668-12

HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir. / Theys, Kristof; Vercauteren, Jurgen; Snoeck, Joke; Zazzi, Maurizio; Camacho, Ricardo Jorge; Torti, Carlo; Schülter, Eugen; Clotet, Bonaventura; Sonnerborg, A; De Luca, A.; Grossman, Zehava; Struck, Daniel; Vandamme, Anne-mieke ; Abecasis, Ana.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 2, 01.01.2013, p. 1053-6.

Research output: Contribution to journal › Article

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AU - Zazzi, Maurizio

AU - Camacho, Ricardo Jorge

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AU - Schülter, Eugen

AU - Clotet, Bonaventura

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AB - Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.

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