Highly water soluble room temperature superionic liquids of APIs

Gonçalo V. S. M. Carrera; Miguel M. Santos; Alexandra Costa; Luis Paulo N. Rebelo; Isabel M. Marrucho; M. Nunes da Ponte; Luis C. Branco

doi:10.1039/c7nj01398a

Highly water soluble room temperature superionic liquids of APIs

Gonçalo V. S. M. Carrera, Miguel M. Santos, Alexandra Costa, Luis Paulo N. Rebelo, Isabel M. Marrucho, M. Nunes da Ponte, Luis C. Branco

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Abstract

Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by ¹H and ¹³C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

Original language	English
Pages (from-to)	6986-6990
Number of pages	5
Journal	New Journal of Chemistry
Volume	41
Issue number	15
DOIs	https://doi.org/10.1039/c7nj01398a
Publication status	Published - 7 Aug 2017

Keywords

PROTIC IONIC LIQUIDS
ACTIVE PHARMACEUTICAL INGREDIENTS
AMPICILLIN
FORMS
CIPROFLOXACIN
ACID
NORFLOXACIN
STABILITY
LIPOSOMES

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NJChem_MMSantos_2017Accepted author manuscript, 1.21 MB

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title = "Highly water soluble room temperature superionic liquids of APIs",

abstract = "Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.",

keywords = "PROTIC IONIC LIQUIDS, ACTIVE PHARMACEUTICAL INGREDIENTS, AMPICILLIN, FORMS, CIPROFLOXACIN, ACID, NORFLOXACIN, STABILITY, LIPOSOMES",

author = "Carrera, {Gon{\c c}alo V. S. M.} and Santos, {Miguel M.} and Alexandra Costa and Rebelo, {Luis Paulo N.} and Marrucho, {Isabel M.} and {Nunes da Ponte}, M. and Branco, {Luis C.}",

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year = "2017",

month = aug,

day = "7",

doi = "10.1039/c7nj01398a",

language = "English",

volume = "41",

pages = "6986--6990",

journal = "New Journal of Chemistry",

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publisher = "RSC - Royal Society of Chemistry",

number = "15",

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TY - JOUR

T1 - Highly water soluble room temperature superionic liquids of APIs

AU - Carrera, Gonçalo V. S. M.

AU - Santos, Miguel M.

AU - Costa, Alexandra

AU - Rebelo, Luis Paulo N.

AU - Marrucho, Isabel M.

AU - Nunes da Ponte, M.

AU - Branco, Luis C.

N1 - info:eu-repo/grantAgreement/FCT/3599-PPCDT/103664/PT# info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F72095%2F2010/PT# Fundacao para a Ciencia e a Tecnologia through project (PEst-C/LA0006/2013). The authors also thank Prof. Madalena Dionisio and Dr Natalia Correia for their support with the DSC analyses.

PY - 2017/8/7

Y1 - 2017/8/7

N2 - Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

AB - Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

KW - PROTIC IONIC LIQUIDS

KW - ACTIVE PHARMACEUTICAL INGREDIENTS

KW - AMPICILLIN

KW - FORMS

KW - CIPROFLOXACIN

KW - ACID

KW - NORFLOXACIN

KW - STABILITY

KW - LIPOSOMES

UR - http://www.scopus.com/inward/record.url?scp=85026320974&partnerID=8YFLogxK

U2 - 10.1039/c7nj01398a

DO - 10.1039/c7nj01398a

M3 - Article

AN - SCOPUS:85026320974

SN - 1144-0546

VL - 41

SP - 6986

EP - 6990

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 15

ER -

Highly water soluble room temperature superionic liquids of APIs

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Keywords

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