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Abstract

Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by 1H and 13C NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs.

Original languageEnglish
Pages (from-to)6986-6990
Number of pages5
JournalNew Journal of Chemistry
Volume41
Issue number15
DOIs
Publication statusPublished - 7 Aug 2017

Keywords

  • PROTIC IONIC LIQUIDS
  • ACTIVE PHARMACEUTICAL INGREDIENTS
  • AMPICILLIN
  • FORMS
  • CIPROFLOXACIN
  • ACID
  • NORFLOXACIN
  • STABILITY
  • LIPOSOMES

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