Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution

Julie Pineau; Luís M.P. Lima; Marie M. Le Roy; Séverine Marionneau-Lambot; Marie Cordier; Patricia Le Saëc; Jan Rijn Zeevaart; Cathryn H.S. Driver; Alain Faivre-Chauvet; Nathalie Le Bris; Raphaël Tripier

doi:10.1039/d2cc06602e

Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable ⁶⁴Cu-labelling and biodistribution

Julie Pineau, Luís M.P. Lima, Marie M. Le Roy, Séverine Marionneau-Lambot, Marie Cordier, Patricia Le Saëc, Jan Rijn Zeevaart, Cathryn H.S. Driver, Alain Faivre-Chauvet, Nathalie Le Bris, Raphaël Tripier

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding ⁶⁴Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.

Original language	English
Pages (from-to)	888-891
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	7
DOIs	https://doi.org/10.1039/d2cc06602e
Publication status	Published - 21 Dec 2022

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10.1039/d2cc06602e

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Pineau, J., Lima, L. M. P., Le Roy, M. M., Marionneau-Lambot, S., Cordier, M., Le Saëc, P., Zeevaart, J. R., Driver, C. H. S., Faivre-Chauvet, A., Le Bris, N., & Tripier, R. (2022). Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable ⁶⁴Cu-labelling and biodistribution. Chemical Communications, 59(7), 888-891. https://doi.org/10.1039/d2cc06602e

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abstract = "Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.",

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doi = "10.1039/d2cc06602e",

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Pineau, J, Lima, LMP, Le Roy, MM, Marionneau-Lambot, S, Cordier, M, Le Saëc, P, Zeevaart, JR, Driver, CHS, Faivre-Chauvet, A, Le Bris, N & Tripier, R 2022, 'Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable ⁶⁴Cu-labelling and biodistribution', Chemical Communications, vol. 59, no. 7, pp. 888-891. https://doi.org/10.1039/d2cc06602e

TY - JOUR

T1 - Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution

AU - Pineau, Julie

AU - Lima, Luís M.P.

AU - Le Roy, Marie M.

AU - Marionneau-Lambot, Séverine

AU - Cordier, Marie

AU - Le Saëc, Patricia

AU - Zeevaart, Jan Rijn

AU - Driver, Cathryn H.S.

AU - Faivre-Chauvet, Alain

AU - Le Bris, Nathalie

AU - Tripier, Raphaël

PY - 2022/12/21

Y1 - 2022/12/21

N2 - Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.

AB - Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.

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U2 - 10.1039/d2cc06602e

DO - 10.1039/d2cc06602e

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AN - SCOPUS:85146286337

SN - 1359-7345

VL - 59

SP - 888

EP - 891

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable ⁶⁴Cu-labelling and biodistribution

Abstract

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