TY - JOUR
T1 - Higher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patients
AU - Adragao, Teresa
AU - Ferreira, Anibal
AU - Frazao, Joao M.
AU - Papoila, Ana Luisa
AU - Pinto, Iola
AU - Monier-Faugere, Marie Claude
AU - Malluche, Hartmut H.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background and objectives In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. Design, setting, participants and measurements In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). Results SVCS3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS3 versus 4% of patients with a SVCS<3, (p<0.001). Conclusion Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.
AB - Background and objectives In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. Design, setting, participants and measurements In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). Results SVCS3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS3 versus 4% of patients with a SVCS<3, (p<0.001). Conclusion Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.
KW - STAGE RENAL-DISEASE
KW - CORONARY-ARTERY CALCIFICATION
KW - CARDIOVASCULAR RISK
KW - CALCIUM
KW - DIALYSIS
KW - OSTEODYSTROPHY
KW - MORTALITY
KW - STIFFNESS
KW - HISTOMORPHOMETRY
KW - PROGRESSION
UR - http://www.scopus.com/inward/record.url?scp=85022183209&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0179868
DO - 10.1371/journal.pone.0179868
M3 - Article
C2 - 28686736
AN - SCOPUS:85022183209
SN - 1932-6203
VL - 12
SP - Online
JO - PLoS ONE
JF - PLoS ONE
IS - 7
M1 - e0179868
ER -