High prevalence of biocide resistance determinants in Staphylococcus aureus isolates from three African countries

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Abstract

We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

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Disinfectants
Staphylococcus aureus
Methicillin
Chlorhexidine
Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
Genes

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title = "High prevalence of biocide resistance determinants in Staphylococcus aureus isolates from three African countries",
abstract = "We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3{\%}), mepA (89.4{\%}), and norA (86.4{\%}), intermediate for lmrS (60.8{\%}) and qacAB (40.5{\%}), and low for smr (3.7{\%}). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.",
author = "Teresa Concei{\cc}{\~a}o and C{\'e}line Coelho and {De Lencastre}, Herm{\'i}nia and Marta Aires-De-Sousa",
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T1 - High prevalence of biocide resistance determinants in Staphylococcus aureus isolates from three African countries

AU - Conceição, Teresa

AU - Coelho, Céline

AU - De Lencastre, Hermínia

AU - Aires-De-Sousa, Marta

PY - 2016/1/1

Y1 - 2016/1/1

N2 - We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.

AB - We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.

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DO - 10.1128/AAC.02140-15

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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