High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy

The first evidence of JC virus as a potential oncovirus in bladder cancer

Sara Querido, Isabel Fernandes, André Weigert, Sandra Casimiro, Catarina Albuquerque, Sância Ramos, Teresa Adragão, Ivan Luz, Paulo Paixão, Maria Chasqueira, Madalena Santos, Domingos Machado

Research output: Contribution to journalArticle

Abstract

Kidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation. Neoplastic tissue was positive for JCV DNA by real-time polymerase chain reaction (PCR). Immunochemical staining showed strong positivity for cell cycle markers (p16, p53, and Ki67) and for early viral protein JCV large T antigen (JCV LTag; using a broad polyomavirus antibody); however, late viral protein (VP1) stained negative. In contrast, in non-neoplastic urothelium, JCV DNA and all immunochemical markers were negative. These facts suggest that malignancy was induced by JCV. To the best of our knowledge, this is the first report of urothelial high-grade carcinoma associated with JCV nephropathy in a KT recipient.

Original languageEnglish
JournalAmerican Journal of Transplantation
DOIs
Publication statusPublished - 2019

Fingerprint

JC Virus
Retroviridae
Urinary Bladder Neoplasms
Carcinoma
Kidney
Viral Proteins
BK Virus
Urothelium
Neoplasms
Polyomavirus
Transplant Recipients
Viral Tumor Antigens
DNA
Kidney Transplantation
Real-Time Polymerase Chain Reaction
Cell Cycle
Staining and Labeling
Antibodies

Keywords

  • cancer
  • clinical research
  • histopathology
  • infection and infectious agents – viral
  • infection and infectious agents – viral: BK
  • JC
  • kidney disease: infectious
  • kidney transplantation
  • malignancy
  • neoplasia: metastatic disease
  • neoplasia: risk factors
  • nephrology
  • pathology
  • polyoma
  • practice
  • urology

Cite this

Querido, Sara ; Fernandes, Isabel ; Weigert, André ; Casimiro, Sandra ; Albuquerque, Catarina ; Ramos, Sância ; Adragão, Teresa ; Luz, Ivan ; Paixão, Paulo ; Chasqueira, Maria ; Santos, Madalena ; Machado, Domingos. / High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy : The first evidence of JC virus as a potential oncovirus in bladder cancer. In: American Journal of Transplantation. 2019.
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abstract = "Kidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation. Neoplastic tissue was positive for JCV DNA by real-time polymerase chain reaction (PCR). Immunochemical staining showed strong positivity for cell cycle markers (p16, p53, and Ki67) and for early viral protein JCV large T antigen (JCV LTag; using a broad polyomavirus antibody); however, late viral protein (VP1) stained negative. In contrast, in non-neoplastic urothelium, JCV DNA and all immunochemical markers were negative. These facts suggest that malignancy was induced by JCV. To the best of our knowledge, this is the first report of urothelial high-grade carcinoma associated with JCV nephropathy in a KT recipient.",
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High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy : The first evidence of JC virus as a potential oncovirus in bladder cancer. / Querido, Sara; Fernandes, Isabel; Weigert, André; Casimiro, Sandra; Albuquerque, Catarina; Ramos, Sância; Adragão, Teresa; Luz, Ivan; Paixão, Paulo; Chasqueira, Maria; Santos, Madalena; Machado, Domingos.

In: American Journal of Transplantation, 2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy

T2 - The first evidence of JC virus as a potential oncovirus in bladder cancer

AU - Querido, Sara

AU - Fernandes, Isabel

AU - Weigert, André

AU - Casimiro, Sandra

AU - Albuquerque, Catarina

AU - Ramos, Sância

AU - Adragão, Teresa

AU - Luz, Ivan

AU - Paixão, Paulo

AU - Chasqueira, Maria

AU - Santos, Madalena

AU - Machado, Domingos

PY - 2019

Y1 - 2019

N2 - Kidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation. Neoplastic tissue was positive for JCV DNA by real-time polymerase chain reaction (PCR). Immunochemical staining showed strong positivity for cell cycle markers (p16, p53, and Ki67) and for early viral protein JCV large T antigen (JCV LTag; using a broad polyomavirus antibody); however, late viral protein (VP1) stained negative. In contrast, in non-neoplastic urothelium, JCV DNA and all immunochemical markers were negative. These facts suggest that malignancy was induced by JCV. To the best of our knowledge, this is the first report of urothelial high-grade carcinoma associated with JCV nephropathy in a KT recipient.

AB - Kidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high-grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after kidney transplantation. Neoplastic tissue was positive for JCV DNA by real-time polymerase chain reaction (PCR). Immunochemical staining showed strong positivity for cell cycle markers (p16, p53, and Ki67) and for early viral protein JCV large T antigen (JCV LTag; using a broad polyomavirus antibody); however, late viral protein (VP1) stained negative. In contrast, in non-neoplastic urothelium, JCV DNA and all immunochemical markers were negative. These facts suggest that malignancy was induced by JCV. To the best of our knowledge, this is the first report of urothelial high-grade carcinoma associated with JCV nephropathy in a KT recipient.

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KW - neoplasia: metastatic disease

KW - neoplasia: risk factors

KW - nephrology

KW - pathology

KW - polyoma

KW - practice

KW - urology

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M3 - Article

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JF - American Journal of Transplantation

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