High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model

Marina Cracchiolo, Joana F. Sacramento, Alberto Mazzoni, Alessandro Panarese, Jacopo Carpaneto, Silvia V. Conde, Silvestro Micera

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Overactivity of the sympathetic nervous system (SNS) is associated to several cardiovascular and metabolic dysfunctions, such as hypertension and insulin resistance. Indirect biochemical measurements and surgical manipulations have provided preliminary evidences about a crucial role of the Carotid Sinus Nerve (CSN) in generating the SNS overactivity. However, CSN and SNS neural activities and their interplay have not been yet characterized in healthy and pathological conditions. Understanding this relationship is key for the development of electroceutical approaches to deliver therapeutic neuromodulation to the autonomic nervous system and restore insulin sensitivity. Here we show that early type 2 diabetes rats present a high frequency shift in both CSN and SNS neural activities with respect to control animals. This feature could be an important neural signature characterizing type 2 diabetes. Moreover, we show that CSN resection in early type 2 diabetes rats abolishes SNS high frequency shift confirming that normal SNS activity and insulin sensitivity may be recovered by CSN activity suppression. These findings shed new light on the pathological neural changes within the autonomic nervous system in type 2 diabetes. Moreover, they pave the way for electrical monitoring of the metabolic state of diabetic patients, a key first step for the development of electroceutical therapies.

Original languageEnglish
Title of host publication9th International IEEE EMBS Conference on Neural Engineering, NER 2019
PublisherIEEE Computer Society
Pages498-501
Number of pages4
ISBN (Electronic)9781538679210
DOIs
Publication statusPublished - 16 May 2019
Event9th International IEEE EMBS Conference on Neural Engineering, NER 2019 - San Francisco, United States
Duration: 20 Mar 201923 Mar 2019

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2019-March
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference9th International IEEE EMBS Conference on Neural Engineering, NER 2019
CountryUnited States
CitySan Francisco
Period20/03/1923/03/19

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  • Cite this

    Cracchiolo, M., Sacramento, J. F., Mazzoni, A., Panarese, A., Carpaneto, J., Conde, S. V., & Micera, S. (2019). High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model. In 9th International IEEE EMBS Conference on Neural Engineering, NER 2019 (pp. 498-501). [8717052] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2019-March). IEEE Computer Society. https://doi.org/10.1109/NER.2019.8717052