TY - JOUR
T1 - Herbicide and Cytogenotoxic Activity of Inclusion Complexes of Psidium gaudichaudianum Leaf Essential Oil and β-Caryophyllene on 2-Hydroxypropyl-β-cyclodextrin
AU - Mendes, Luiza Alves
AU - Vasconcelos, Loren Cristina
AU - Fontes, Milene Miranda Praça
AU - Martins, Geisiele Silva
AU - Bergamin, Aline dos Santos
AU - Silva, Matheus Alves
AU - Silva, Rafael Resende Assis
AU - Oliveira, Taíla Veloso de
AU - Souza, Victor Gomes Lauriano
AU - Ferreira, Márcia Flores da Silva
AU - Teixeira, Róbson Ricardo
AU - Lopes, Renata Pereira
N1 - Funding Information:
We would like to thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), and Fundação de Amparo à Pesquisa e Inovação do Espírito Santo (FAPES) for financial support.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/8/6
Y1 - 2023/8/6
N2 - The present investigation aimed to develop inclusion complexes (ICs) from Psidium gaudichaudianum (GAU) essential oil (EO) and its major compound β-caryophyllene (β-CAR), and to evaluate their herbicidal (against Lolium multiflorum and Bidens pilosa) and cytogenotoxic (on Lactuca sativa) activities. The ICs were obtained using 2-hydroxypropyl-β-cyclodextrin (HPβCD) and they were prepared to avoid or reduce the volatility and degradation of GAU EO and β-CAR. The ICs obtained showed a complexation efficiency of 91.5 and 83.9% for GAU EO and β-CAR, respectively. The IC of GAU EO at a concentration of 3000 µg mL−1 displayed a significant effect against weed species B. pilosa and L. multiflorum. However, the β-CAR IC at a concentration of 3000 µg mL−1 was effective only on L. multiflorum. In addition, the cytogenotoxic activity evaluation revealed that there was a reduction in the mitotic index and an increase in chromosomal abnormalities. The produced ICs were able to protect the EO and β-CAR from volatility and degradation, with a high thermal stability, and they also enabled the solubilization of the EO and β-CAR in water without the addition of an organic solvent. Therefore, it is possible to indicate the obtained products as potential candidates for commercial exploration since the ICs allow the complexed EO to exhibit a more stable chemical constitution than pure EO under storage conditions.
AB - The present investigation aimed to develop inclusion complexes (ICs) from Psidium gaudichaudianum (GAU) essential oil (EO) and its major compound β-caryophyllene (β-CAR), and to evaluate their herbicidal (against Lolium multiflorum and Bidens pilosa) and cytogenotoxic (on Lactuca sativa) activities. The ICs were obtained using 2-hydroxypropyl-β-cyclodextrin (HPβCD) and they were prepared to avoid or reduce the volatility and degradation of GAU EO and β-CAR. The ICs obtained showed a complexation efficiency of 91.5 and 83.9% for GAU EO and β-CAR, respectively. The IC of GAU EO at a concentration of 3000 µg mL−1 displayed a significant effect against weed species B. pilosa and L. multiflorum. However, the β-CAR IC at a concentration of 3000 µg mL−1 was effective only on L. multiflorum. In addition, the cytogenotoxic activity evaluation revealed that there was a reduction in the mitotic index and an increase in chromosomal abnormalities. The produced ICs were able to protect the EO and β-CAR from volatility and degradation, with a high thermal stability, and they also enabled the solubilization of the EO and β-CAR in water without the addition of an organic solvent. Therefore, it is possible to indicate the obtained products as potential candidates for commercial exploration since the ICs allow the complexed EO to exhibit a more stable chemical constitution than pure EO under storage conditions.
KW - araçá
KW - bioherbicide
KW - biological activity
KW - inclusion complex
KW - natural product
UR - http://www.scopus.com/inward/record.url?scp=85167835526&partnerID=8YFLogxK
U2 - 10.3390/molecules28155909
DO - 10.3390/molecules28155909
M3 - Article
C2 - 37570879
AN - SCOPUS:85167835526
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 15
M1 - 5909
ER -
