Hepatitis C virus infection

beyond the liver

Arrais de Castro, R., Vilas, P, J Borges-Costa, Rui Tato Marinho

Research output: Contribution to journalArticle

Abstract

There are rare reports of association between hepatitis C virus (HCV) infection and dermatomyositis although cause and effect remains to be proven. We present a clinical case with a probable cause and effect association between these two entities. A 71-year-old woman developed an erythematous exanthem with pruritic and scaly lesions located at the torso and upper limbs associated with heliotrope and Gottron's papules. At the same time, she notice a significant loss of muscular strength. Skin and muscular biopsies made the diagnosis of dermatomyositis and the patient started with prednisolone (60 mg/day) with poor symptoms control. Paraneoplastic syndrome, HIV, hepatitis B virus and syphilis infections were excluded. HCV serology was positive, with a viral load of 58 159 IU/mL (genotype 1a). Therefore, the patient underwent a 12-week treatment with grazoprevir 100 mg and elbasvir 50 mg achieving a sustained virological response with regression of skin lesions and complete recovery of muscular strength (photodocumented before/after treatment). Additionally it was possible to reduce prednisolone dosage to 5 mg/day.
Original languageEnglish
Article number225817
JournalBMJ case reports
DOIs
Publication statusPublished - 25 Jul 2018

Fingerprint

Dermatomyositis
Virus Diseases
Prednisolone
Hepacivirus
Paraneoplastic Syndromes
Torso
Skin
Liver
Serology
Syphilis
Exanthema
Viral Load
Hepatitis B virus
Upper Extremity
Genotype
HIV
Biopsy
Therapeutics
2-(pyrrolidin-2-yl)-5-(2-(4-(5-(pyrrolidin-2-yl)-1H-imidazol-2-yl)phenyl)benzofuran-5-yl)-1H-imidazole
MK-5172

Keywords

  • Dermatology
  • Hepatitis C

Cite this

R., Arrais de Castro, ; P, Vilas, ; Borges-Costa, J ; Marinho, Rui Tato. / Hepatitis C virus infection : beyond the liver. In: BMJ case reports. 2018.
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abstract = "There are rare reports of association between hepatitis C virus (HCV) infection and dermatomyositis although cause and effect remains to be proven. We present a clinical case with a probable cause and effect association between these two entities. A 71-year-old woman developed an erythematous exanthem with pruritic and scaly lesions located at the torso and upper limbs associated with heliotrope and Gottron's papules. At the same time, she notice a significant loss of muscular strength. Skin and muscular biopsies made the diagnosis of dermatomyositis and the patient started with prednisolone (60 mg/day) with poor symptoms control. Paraneoplastic syndrome, HIV, hepatitis B virus and syphilis infections were excluded. HCV serology was positive, with a viral load of 58 159 IU/mL (genotype 1a). Therefore, the patient underwent a 12-week treatment with grazoprevir 100 mg and elbasvir 50 mg achieving a sustained virological response with regression of skin lesions and complete recovery of muscular strength (photodocumented before/after treatment). Additionally it was possible to reduce prednisolone dosage to 5 mg/day.",
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Hepatitis C virus infection : beyond the liver. / R., Arrais de Castro,; P, Vilas, ; Borges-Costa, J; Marinho, Rui Tato.

In: BMJ case reports, 25.07.2018.

Research output: Contribution to journalArticle

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T2 - beyond the liver

AU - R., Arrais de Castro,

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AU - Borges-Costa, J

AU - Marinho, Rui Tato

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Y1 - 2018/7/25

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AB - There are rare reports of association between hepatitis C virus (HCV) infection and dermatomyositis although cause and effect remains to be proven. We present a clinical case with a probable cause and effect association between these two entities. A 71-year-old woman developed an erythematous exanthem with pruritic and scaly lesions located at the torso and upper limbs associated with heliotrope and Gottron's papules. At the same time, she notice a significant loss of muscular strength. Skin and muscular biopsies made the diagnosis of dermatomyositis and the patient started with prednisolone (60 mg/day) with poor symptoms control. Paraneoplastic syndrome, HIV, hepatitis B virus and syphilis infections were excluded. HCV serology was positive, with a viral load of 58 159 IU/mL (genotype 1a). Therefore, the patient underwent a 12-week treatment with grazoprevir 100 mg and elbasvir 50 mg achieving a sustained virological response with regression of skin lesions and complete recovery of muscular strength (photodocumented before/after treatment). Additionally it was possible to reduce prednisolone dosage to 5 mg/day.

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