Healthcare-resource utilization associated with radiation to bone across eight European countries

Results from a retrospective study

Roger von Moos, Jean Jacques Body, Oliver Guenther, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, João Pereira, Nikos Maniadakis, Guy Hechmati, Susan Talbot, Harm Sleeboom

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Abstract

Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. Eligible patients were ≥ 20 years old, had bone metastases secondary to breast, lung or prostate cancer, or bone lesions associated with multiple myeloma, and had received radiation to bone between 1 July 2004 and 1 July 2009. HRU data were extracted from hospital patient charts from 3.5 months before the index SRE (radiation to bone preceded by a SRE-free period of ≥ 6.5 months) until 3 months after the last SRE that the patient experienced during the study period. Results: In total, 482 patients were included. The number of inpatient stays increased from baseline by a mean of 0.52 (standard deviation [SD] 1.17) stays per radiation to bone event and the duration of stays increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD 7.46) procedures. Conclusion: HRU increased following radiation to bone across all countries studied. Agents that prevent severe pain and delay the need for radiation have the potential to reduce the burden imposed on healthcare resources and patients.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalJournal of Bone Oncology
Volume10
DOIs
Publication statusPublished - 1 Mar 2018

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Retrospective Studies
Radiation
Delivery of Health Care
Bone and Bones
Multiple Myeloma
Neoplasm Metastasis
Bone Neoplasms
Portugal
Austria
Czech Republic
Bone Diseases
Greece
Poland
Finland
Switzerland
Sweden
Inpatients
Lung Neoplasms
Prostatic Neoplasms
Outpatients

Keywords

  • Bone metastases
  • Bone pain
  • Health resource utilization
  • Radiation to bone
  • Skeletal-related event

Cite this

von Moos, Roger ; Body, Jean Jacques ; Guenther, Oliver ; Terpos, Evangelos ; Acklin, Yves Pascal ; Finek, Jindrich ; Pereira, João ; Maniadakis, Nikos ; Hechmati, Guy ; Talbot, Susan ; Sleeboom, Harm. / Healthcare-resource utilization associated with radiation to bone across eight European countries : Results from a retrospective study. In: Journal of Bone Oncology. 2018 ; Vol. 10. pp. 49-56.
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abstract = "Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. Eligible patients were ≥ 20 years old, had bone metastases secondary to breast, lung or prostate cancer, or bone lesions associated with multiple myeloma, and had received radiation to bone between 1 July 2004 and 1 July 2009. HRU data were extracted from hospital patient charts from 3.5 months before the index SRE (radiation to bone preceded by a SRE-free period of ≥ 6.5 months) until 3 months after the last SRE that the patient experienced during the study period. Results: In total, 482 patients were included. The number of inpatient stays increased from baseline by a mean of 0.52 (standard deviation [SD] 1.17) stays per radiation to bone event and the duration of stays increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD 7.46) procedures. Conclusion: HRU increased following radiation to bone across all countries studied. Agents that prevent severe pain and delay the need for radiation have the potential to reduce the burden imposed on healthcare resources and patients.",
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von Moos, R, Body, JJ, Guenther, O, Terpos, E, Acklin, YP, Finek, J, Pereira, J, Maniadakis, N, Hechmati, G, Talbot, S & Sleeboom, H 2018, 'Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study', Journal of Bone Oncology, vol. 10, pp. 49-56. https://doi.org/10.1016/j.jbo.2018.01.003

Healthcare-resource utilization associated with radiation to bone across eight European countries : Results from a retrospective study. / von Moos, Roger; Body, Jean Jacques; Guenther, Oliver; Terpos, Evangelos; Acklin, Yves Pascal; Finek, Jindrich; Pereira, João; Maniadakis, Nikos; Hechmati, Guy; Talbot, Susan; Sleeboom, Harm.

In: Journal of Bone Oncology, Vol. 10, 01.03.2018, p. 49-56.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Healthcare-resource utilization associated with radiation to bone across eight European countries

T2 - Results from a retrospective study

AU - von Moos, Roger

AU - Body, Jean Jacques

AU - Guenther, Oliver

AU - Terpos, Evangelos

AU - Acklin, Yves Pascal

AU - Finek, Jindrich

AU - Pereira, João

AU - Maniadakis, Nikos

AU - Hechmati, Guy

AU - Talbot, Susan

AU - Sleeboom, Harm

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. Eligible patients were ≥ 20 years old, had bone metastases secondary to breast, lung or prostate cancer, or bone lesions associated with multiple myeloma, and had received radiation to bone between 1 July 2004 and 1 July 2009. HRU data were extracted from hospital patient charts from 3.5 months before the index SRE (radiation to bone preceded by a SRE-free period of ≥ 6.5 months) until 3 months after the last SRE that the patient experienced during the study period. Results: In total, 482 patients were included. The number of inpatient stays increased from baseline by a mean of 0.52 (standard deviation [SD] 1.17) stays per radiation to bone event and the duration of stays increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD 7.46) procedures. Conclusion: HRU increased following radiation to bone across all countries studied. Agents that prevent severe pain and delay the need for radiation have the potential to reduce the burden imposed on healthcare resources and patients.

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KW - Bone metastases

KW - Bone pain

KW - Health resource utilization

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KW - Skeletal-related event

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