Health resource utilization associated with skeletal-related events

results from a retrospective European study

Jean Jacques Body, João Pereira, Harm Sleeboom, Nikos Maniadakis, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, Oliver Gunther, Guy Hechmati, Tony Mossman, Luis Costa, Wojciech Rogowski, Hareth Nahi, Roger von Moos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Bone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers. Objective: To provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries. Methods: Eligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients’ charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months). Results: Overall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5–1.5 stays, with increases in the total duration of inpatient stays of approximately 6–37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits. Conclusions: SREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems.

Original languageEnglish
Pages (from-to)711-721
Number of pages11
JournalEuropean Journal Of Health Economics
Volume17
Issue number6
DOIs
Publication statusPublished - 1 Jul 2016

Fingerprint

Health Resources
Retrospective Studies
Bone and Bones
Inpatients
Spontaneous Fractures
Bone Fractures
Lung Neoplasms
Prostatic Neoplasms
Neoplasm Metastasis
Spinal Cord Compression
Portugal
Austria
Czech Republic
Greece
Poland
Finland
Ambulatory Care
Multiple Myeloma
Switzerland
Sweden

Keywords

  • Bone metastases
  • Breast cancer
  • Health resource utilization (HRU)
  • Lung cancer
  • Prostate cancer
  • Skeletal-related event (SRE)

Cite this

Body, Jean Jacques ; Pereira, João ; Sleeboom, Harm ; Maniadakis, Nikos ; Terpos, Evangelos ; Acklin, Yves Pascal ; Finek, Jindrich ; Gunther, Oliver ; Hechmati, Guy ; Mossman, Tony ; Costa, Luis ; Rogowski, Wojciech ; Nahi, Hareth ; von Moos, Roger. / Health resource utilization associated with skeletal-related events : results from a retrospective European study. In: European Journal Of Health Economics. 2016 ; Vol. 17, No. 6. pp. 711-721.
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title = "Health resource utilization associated with skeletal-related events: results from a retrospective European study",
abstract = "Background: Bone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers. Objective: To provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries. Methods: Eligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients’ charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months). Results: Overall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5–1.5 stays, with increases in the total duration of inpatient stays of approximately 6–37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits. Conclusions: SREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems.",
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Body, JJ, Pereira, J, Sleeboom, H, Maniadakis, N, Terpos, E, Acklin, YP, Finek, J, Gunther, O, Hechmati, G, Mossman, T, Costa, L, Rogowski, W, Nahi, H & von Moos, R 2016, 'Health resource utilization associated with skeletal-related events: results from a retrospective European study', European Journal Of Health Economics, vol. 17, no. 6, pp. 711-721. https://doi.org/10.1007/s10198-015-0716-7

Health resource utilization associated with skeletal-related events : results from a retrospective European study. / Body, Jean Jacques; Pereira, João; Sleeboom, Harm; Maniadakis, Nikos; Terpos, Evangelos; Acklin, Yves Pascal; Finek, Jindrich; Gunther, Oliver; Hechmati, Guy; Mossman, Tony; Costa, Luis; Rogowski, Wojciech; Nahi, Hareth; von Moos, Roger.

In: European Journal Of Health Economics, Vol. 17, No. 6, 01.07.2016, p. 711-721.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Health resource utilization associated with skeletal-related events

T2 - results from a retrospective European study

AU - Body, Jean Jacques

AU - Pereira, João

AU - Sleeboom, Harm

AU - Maniadakis, Nikos

AU - Terpos, Evangelos

AU - Acklin, Yves Pascal

AU - Finek, Jindrich

AU - Gunther, Oliver

AU - Hechmati, Guy

AU - Mossman, Tony

AU - Costa, Luis

AU - Rogowski, Wojciech

AU - Nahi, Hareth

AU - von Moos, Roger

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: Bone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers. Objective: To provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries. Methods: Eligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients’ charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months). Results: Overall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5–1.5 stays, with increases in the total duration of inpatient stays of approximately 6–37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits. Conclusions: SREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems.

AB - Background: Bone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers. Objective: To provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries. Methods: Eligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients’ charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months). Results: Overall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5–1.5 stays, with increases in the total duration of inpatient stays of approximately 6–37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits. Conclusions: SREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems.

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KW - Breast cancer

KW - Health resource utilization (HRU)

KW - Lung cancer

KW - Prostate cancer

KW - Skeletal-related event (SRE)

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