Health resource utilization associated with skeletal-related events: results from a retrospective European study

Jean Jacques Body, João Pereira, Harm Sleeboom, Nikos Maniadakis, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, Oliver Gunther, Guy Hechmati, Tony Mossman, Luis Costa, Wojciech Rogowski, Hareth Nahi, Roger von Moos

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Background: Bone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers. Objective: To provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries. Methods: Eligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients’ charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months). Results: Overall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5–1.5 stays, with increases in the total duration of inpatient stays of approximately 6–37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits. Conclusions: SREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems.

Original languageEnglish
Pages (from-to)711-721
Number of pages11
JournalEuropean Journal Of Health Economics
Issue number6
Publication statusPublished - 1 Jul 2016


  • Bone metastases
  • Breast cancer
  • Health resource utilization (HRU)
  • Lung cancer
  • Prostate cancer
  • Skeletal-related event (SRE)


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