Nevirapine (NVP) has been associated with severe and life-threatening idiosyncratic reactions. The mechanisms underlying NVP toxicity are not fully understood but drug bioactivation to reactive metabolites capable of forming stable protein and DNA adducts is thought to be involved. This work represents the first evidence for the formation of NVP-derived hemoglobin (Hb) adducts in man. Moreover, the consistent occurrence of NVP bioactivation, combined with the high inter-individual variability found in adduct formation, provides clues to the molecular mechanisms underlying NVP-induced toxic reactions.
|Title of host publication||PROCEEDINGS OF THE 6TH EUROPEAN CONGRESS OF PHARMACOLOGY|
|Publication status||Published - 1 Jan 2013|
|Event||6th European Congress of Pharmacology Local: Granada, SPAIN Data: JUL 17-20, 2012 Patrocinador(es): EPHAR - |
Duration: 1 Jan 2012 → …
|Conference||6th European Congress of Pharmacology Local: Granada, SPAIN Data: JUL 17-20, 2012 Patrocinador(es): EPHAR|
|Period||1/01/12 → …|