TY - JOUR
T1 - Hallmarks of the human intestinal microbiome on liver maturation and function
AU - Almeida, Joana I.
AU - Tenreiro, Miguel F.
AU - Martinez-Santamaria, Lucía
AU - Guerrero-Aspizua, Sara
AU - Gisbert, Javier P.
AU - Alves, Paula M.
AU - Serra, Margarida
AU - Baptista, Pedro M.
N1 - Funding Information:
JIA, PMA and MS were supported by iNOVA4Health ? UIDB/04462/2020 and UIDP/04462/2020, a programme financially supported by Funda??o para a Ci?ncia e Tecnologia/Minist?rio da Ci?ncia, Tecnologia e Ensino Superior, through national funds. JIA was supported by the PhD fellowship received from Funda??o para a Ci?ncia e Tecnologia, Portugal (SFRH/BD/116780/2016). PMB was supported by the PI18/00529 Research Project from Instituto de Salud Carlos III, Spain, LMP226_18 Research Project from Diputaci?n General de Arag?n, Spain and CIBEREHD EHD16PI02 from CIBERehd, Spain.
Funding Information:
JIA, PMA and MS were supported by iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, a programme financially supported by Fundação para a Ciência e Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior , through national funds. JIA was supported by the PhD fellowship received from Fundação para a Ciência e Tecnologia , Portugal ( SFRH/BD/116780/2016 ). PMB was supported by the PI18/00529 Research Project from Instituto de Salud Carlos III , Spain, LMP226_18 Research Project from Diputación General de Aragón, Spain and CIBEREHD EHD16PI02 from CIBERehd , Spain.
Publisher Copyright:
© 2021 European Association for the Study of the Liver
PY - 2021
Y1 - 2021
N2 - As one of the most metabolically complex systems in the body, the liver ensures multi-organ homeostasis and ultimately sustains life. Nevertheless, during early postnatal development, the liver is highly immature and takes about 2 years to acquire and develop almost all of its functions. Different events occurring at the environmental and cellular levels are thought to mediate hepatic maturation and function postnatally. The crosstalk between the liver, the gut and its microbiome has been well appreciated in the context of liver disease, but recent evidence suggests that the latter could also be critical for hepatic function under physiological conditions. The gut-liver crosstalk is thought to be mediated by a rich repertoire of microbial metabolites that can participate in a myriad of biological processes in hepatic sinusoids, from energy metabolism to tissue regeneration. Studies on germ-free animals have revealed the gut microbiome as a critical contributor in early hepatic programming, and this influence extends throughout life, mediating liver function and body homeostasis. In this seminar, we describe the microbial molecules that have a known effect on the liver and discuss how the gut microbiome and the liver evolve throughout life. We also provide insights on current and future strategies to target the gut microbiome in the context of hepatology research.
AB - As one of the most metabolically complex systems in the body, the liver ensures multi-organ homeostasis and ultimately sustains life. Nevertheless, during early postnatal development, the liver is highly immature and takes about 2 years to acquire and develop almost all of its functions. Different events occurring at the environmental and cellular levels are thought to mediate hepatic maturation and function postnatally. The crosstalk between the liver, the gut and its microbiome has been well appreciated in the context of liver disease, but recent evidence suggests that the latter could also be critical for hepatic function under physiological conditions. The gut-liver crosstalk is thought to be mediated by a rich repertoire of microbial metabolites that can participate in a myriad of biological processes in hepatic sinusoids, from energy metabolism to tissue regeneration. Studies on germ-free animals have revealed the gut microbiome as a critical contributor in early hepatic programming, and this influence extends throughout life, mediating liver function and body homeostasis. In this seminar, we describe the microbial molecules that have a known effect on the liver and discuss how the gut microbiome and the liver evolve throughout life. We also provide insights on current and future strategies to target the gut microbiome in the context of hepatology research.
KW - hepatic maturation and function
KW - human intestinal microbiome
KW - Liver development
KW - microbial metabolites
KW - microbiota
UR - http://www.scopus.com/inward/record.url?scp=85121986900&partnerID=8YFLogxK
U2 - 10.1016/j.jhep.2021.10.015
DO - 10.1016/j.jhep.2021.10.015
M3 - Review article
C2 - 34715263
AN - SCOPUS:85121986900
SN - 0168-8278
JO - Journal Of Hepatology
JF - Journal Of Hepatology
ER -