Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Jean-Yves L Reginster, Nigel K Arden, Ida K Haugen, Francois Rannou, Etienne Cavalier, Olivier Bruyère, Jaime Branco, Roland Chapurlat, Sabine Collaud Basset, Nasser M Al-Daghri, Elaine M Dennison, Gabriel Herrero-Beaumont, Andrea Laslop, Burkhard F Leeb, Stefania Maggi, Ouafa Mkinsi, Anton S Povzun, Daniel Prieto-Alhambra, Thierry Thomas, Daniel UebelhartNicola Veronese, Cyrus Cooper

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

OBJECTIVES: To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need.

METHODS: The European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO) organized a working group under the auspices of the International Osteoporosis Foundation (IOF) and the World Health Organization (WHO).

RESULTS: This consensus guideline is intended to provide a reference tool for practice, and should allow for better standardization of the conduct of clinical trials in hand OA. Hand OA is a heterogeneous disease affecting different, and often multiple, joints of the thumb and fingers. It was recognized that the various phenotypes and limitations of diagnostic criteria may make the results of hand OA trials difficult to interpret. Nonetheless, practical recommendations for the conduct of clinical trials of both symptom and structure modifying drugs are outlined in this consensus statement, including guidance on study design, execution, and analysis.

CONCLUSIONS: While the working group acknowledges that the methodology for performing clinical trials in hand OA will evolve as knowledge of the disease increases, it is hoped that this guidance will support the development of new pharmacological treatments targeting hand OA.

Original languageEnglish
Pages (from-to)1-8
JournalSeminars in Arthritis and Rheumatism
Early online date7 Dec 2017
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Hand osteoarthritis
  • Clinical trials
  • Guidelines
  • Pharmacological treatment

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    Reginster, J-Y. L., Arden, N. K., Haugen, I. K., Rannou, F., Cavalier, E., Bruyère, O., Branco, J., Chapurlat, R., Collaud Basset, S., Al-Daghri, N. M., Dennison, E. M., Herrero-Beaumont, G., Laslop, A., Leeb, B. F., Maggi, S., Mkinsi, O., Povzun, A. S., Prieto-Alhambra, D., Thomas, T., ... Cooper, C. (2018). Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Seminars in Arthritis and Rheumatism, 1-8. https://doi.org/10.1016/j.semarthrit.2017.12.003