Abstract
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the authors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the progress of this vibrant field of research.
| Original language | English |
|---|---|
| Pages (from-to) | 4-31 |
| Number of pages | 28 |
| Journal | Microbial Cell |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
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Keywords
- Accidental cell death
- Apoptosis
- Autophagic cell death
- Autophagy
- Caspases
- Mitochondrial membrane permeabilization
- Mitotic catastrophe
- Model organism
- Necrosis
- Reactive oxygen species
- Regulated cell death
- Saccharomyces cerevisiae
Cite this
}
Guidelines and recommendations on yeast cell death nomenclature. / Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; Bar-Nun, Shoshana; Barrientos, Antonio; Belenky, Peter; Blondel, Marc; Braun, Ralf J.; Breitenbach, Michael; Burhans, William C.; Büttner, Sabrina; Cavalieri, Duccio; Chang, Michael; Cooper, Katrina F.; Côrte-Real, Manuela; Costa, Vítor; Cullin, Christophe; Dawes, Ian; Dengjel, Jörn; Dickman, Martin B.; Eisenberg, Tobias; Fahrenkrog, Birthe; Fasel, Nicolas; Fröhlich, Kai Uwe; Gargouri, Ali; Giannattasio, Sergio; Goffrini, Paola; Gourlay, Campbell W.; Grant, Chris M.; Greenwood, Michael T.; Guaragnella, Nicoletta; Heger, Thomas; Heinisch, Jürgen; Herker, Eva; Herrmann, Johannes M.; Hofer, Sebastian; Jiménez-Ruiz, Antonio; Jungwirth, Helmut; Kainz, Katharina; Kontoyiannis, Dimitrios P.; Ludovico, Paula; Manon, Stéphen; Martegani, Enzo; Mazzoni, Cristina; Megeney, Lynn A.; Meisinger, Chris; Nielsen, Jens; Nyström, Thomas; Osiewacz, Heinz D.; Outeiro, Tiago F.; Park, Hay Oak; Pendl, Tobias; Petranovic, Dina; Picot, Stephane; Polčic, Peter; Powers, Ted; Ramsdale, Mark; Rinnerthaler, Mark; Rockenfeller, Patrick; Ruckenstuhl, Christoph; Schaffrath, Raffael; Segovia, Maria; Severin, Fedor F.; Sharon, Amir; Sigrist, Stephan J.; Sommer-Ruck, Cornelia; Sousa, Maria João; Thevelein, Johan M.; Thevissen, Karin; Titorenko, Vladimir; Toledano, Michel B.; Tuite, Mick; Vögtle, F. Nora; Westermann, Benedikt; Winderickx, Joris; Wissing, Silke; Wölfl, Stefan; Zhang, Zhaojie J.; Zhao, Richard Y.; Zhou, Bing; Galluzzi, Lorenzo; Kroemer, Guido; Madeo, Frank.
In: Microbial Cell, Vol. 5, No. 1, 01.01.2018, p. 4-31.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Guidelines and recommendations on yeast cell death nomenclature
AU - Carmona-Gutierrez, Didac
AU - Bauer, Maria Anna
AU - Zimmermann, Andreas
AU - Aguilera, Andrés
AU - Austriaco, Nicanor
AU - Ayscough, Kathryn
AU - Balzan, Rena
AU - Bar-Nun, Shoshana
AU - Barrientos, Antonio
AU - Belenky, Peter
AU - Blondel, Marc
AU - Braun, Ralf J.
AU - Breitenbach, Michael
AU - Burhans, William C.
AU - Büttner, Sabrina
AU - Cavalieri, Duccio
AU - Chang, Michael
AU - Cooper, Katrina F.
AU - Côrte-Real, Manuela
AU - Costa, Vítor
AU - Cullin, Christophe
AU - Dawes, Ian
AU - Dengjel, Jörn
AU - Dickman, Martin B.
AU - Eisenberg, Tobias
AU - Fahrenkrog, Birthe
AU - Fasel, Nicolas
AU - Fröhlich, Kai Uwe
AU - Gargouri, Ali
AU - Giannattasio, Sergio
AU - Goffrini, Paola
AU - Gourlay, Campbell W.
AU - Grant, Chris M.
AU - Greenwood, Michael T.
AU - Guaragnella, Nicoletta
AU - Heger, Thomas
AU - Heinisch, Jürgen
AU - Herker, Eva
AU - Herrmann, Johannes M.
AU - Hofer, Sebastian
AU - Jiménez-Ruiz, Antonio
AU - Jungwirth, Helmut
AU - Kainz, Katharina
AU - Kontoyiannis, Dimitrios P.
AU - Ludovico, Paula
AU - Manon, Stéphen
AU - Martegani, Enzo
AU - Mazzoni, Cristina
AU - Megeney, Lynn A.
AU - Meisinger, Chris
AU - Nielsen, Jens
AU - Nyström, Thomas
AU - Osiewacz, Heinz D.
AU - Outeiro, Tiago F.
AU - Park, Hay Oak
AU - Pendl, Tobias
AU - Petranovic, Dina
AU - Picot, Stephane
AU - Polčic, Peter
AU - Powers, Ted
AU - Ramsdale, Mark
AU - Rinnerthaler, Mark
AU - Rockenfeller, Patrick
AU - Ruckenstuhl, Christoph
AU - Schaffrath, Raffael
AU - Segovia, Maria
AU - Severin, Fedor F.
AU - Sharon, Amir
AU - Sigrist, Stephan J.
AU - Sommer-Ruck, Cornelia
AU - Sousa, Maria João
AU - Thevelein, Johan M.
AU - Thevissen, Karin
AU - Titorenko, Vladimir
AU - Toledano, Michel B.
AU - Tuite, Mick
AU - Vögtle, F. Nora
AU - Westermann, Benedikt
AU - Winderickx, Joris
AU - Wissing, Silke
AU - Wölfl, Stefan
AU - Zhang, Zhaojie J.
AU - Zhao, Richard Y.
AU - Zhou, Bing
AU - Galluzzi, Lorenzo
AU - Kroemer, Guido
AU - Madeo, Frank
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the authors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the progress of this vibrant field of research.
AB - Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death routines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the authors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the progress of this vibrant field of research.
KW - Accidental cell death
KW - Apoptosis
KW - Autophagic cell death
KW - Autophagy
KW - Caspases
KW - Mitochondrial membrane permeabilization
KW - Mitotic catastrophe
KW - Model organism
KW - Necrosis
KW - Reactive oxygen species
KW - Regulated cell death
KW - Saccharomyces cerevisiae
UR - http://www.scopus.com/inward/record.url?scp=85047020782&partnerID=8YFLogxK
U2 - 10.15698/mic2018.01.607
DO - 10.15698/mic2018.01.607
M3 - Review article
VL - 5
SP - 4
EP - 31
JO - Microbial Cell
JF - Microbial Cell
SN - 2311-2638
IS - 1
ER -