Growth of pulmonary circulation in normal pig: Structural analysis and cardiopulmonary function

A. Rendas, M. Branthwaite, L. Reid

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Morphometric analysis of the postnatal development of the pig lung, with emphasis on alveoli and vessels, shows features of growth similar to man, but occurring at a much faster rate in the pig, which telescopes in the first 3 mo the changes seen in human childhood and adolescence. During the first weeks, arteries (birth to 2 wk) and alveoli (1-12 wk) increase in number, whereas increase in size continues until adulthood. Wall thickness decreases soon after birth in arteries 15-200 μm, and by 8 wk in those 200-1,000 μm. At this age the adult left ventricular predominance in weight is already present. Throughout growth the venous wall thickness does not change. Cardiopulmonary function studies in pigs, from 2 to 16 wk, show that, during the period of rapid postnatal lung growth, there is no change in tidal volume, dynamic compliance, and thoracic gas volume as related to body weight; right ventricular and pulmonary arterial pressures also remain unchanged, whereas pulmonary vascular resistance decreases during the 1st mo.

Original languageEnglish
Pages (from-to)806-817
Number of pages12
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume45
Issue number5
Publication statusPublished - 1 Dec 1978

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