Green solvents for enhanced impregnation processes in biomedicine

Alexandre A. Barros, Joana M. Silva, Rita Craveiro, Alexandre Paiva, Rui L. Reis, Ana Rita C. Duarte

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


Supercritical carbon dioxide has been used as a green solvent due to their well-known potential in biomaterials impregnation. The versatility of this technique enables the loading of implants with Active Pharmaceutical Ingredients which present several benefits when compared with traditional techniques to impregnate active compounds. In this review, we have summarized the recent progresses achieved in supercritical CO2 assisted impregnation of active compounds and therapeutic deep eutectic systems for biomedical applications.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalCurrent Opinion in Green and Sustainable Chemistry
Publication statusPublished - Jun 2017


  • Eutectics
  • solvents DESs
  • Ionic liquids


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