Graphene Oxide Thin Films with Drug Delivery Function

Alexandra M.L. Oliveira; Mónica Machado; Gabriela A. Silva; Diogo B. Bitoque; Joana Tavares Ferreira; Luís Abegão Pinto; Quirina Ferreira

doi:10.3390/nano12071149

Graphene Oxide Thin Films with Drug Delivery Function

Alexandra M.L. Oliveira, Mónica Machado, Gabriela A. Silva, Diogo B. Bitoque, Joana Tavares Ferreira, Luís Abegão Pinto, Quirina Ferreira

Research output: Contribution to journal › Review article › peer-review

56 Citations (Scopus)

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Abstract

Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

Original language	English
Article number	1149
Journal	Nanomaterials
Volume	12
Issue number	7
DOIs	https://doi.org/10.3390/nano12071149
Publication status	Published - 30 Mar 2022

Keywords

drug delivery
graphene oxide
layer-by-layer
polyelectrolyte multilayer films

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10.3390/nano12071149Licence: CC BY

nanomaterials-12-01149Final published version, 1.82 MBLicence: CC BY

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title = "Graphene Oxide Thin Films with Drug Delivery Function",

abstract = "Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.",

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AU - Oliveira, Alexandra M.L.

AU - Machado, Mónica

AU - Silva, Gabriela A.

AU - Bitoque, Diogo B.

AU - Ferreira, Joana Tavares

AU - Pinto, Luís Abegão

AU - Ferreira, Quirina

N1 - Funding Information: Funding: Funding was obtained through the Fundação para a Ciência e Tecnologia (FCT) through the projects iNOVA4Health, Translational Medicine program—UIDB/Multi/04462/2020; UIDB/50008/2020 and PTDC/CTM-REF/2679/2020.

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Y1 - 2022/3/30

N2 - Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

AB - Graphene oxide has been used in different fields of nanomedicine as a manager of drug delivery due to its inherent physical and chemical properties that allow its use in thin films with biomedical applications. Several studies demonstrated its efficacy in the control of the amount and the timely delivery of drugs when it is incorporated in multilayer films. It has been demonstrated that oxide graphene layers are able to work as drug delivery or just to delay consecutive drug dosage, allowing the operation of time-controlled systems. This review presents the latest research developments of biomedical applications using graphene oxide as the main component of a drug delivery system, with focus on the production and characterization of films, in vitro and in vivo assays, main applications of graphene oxide biomedical devices, and its biocompatibility properties.

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KW - graphene oxide

KW - layer-by-layer

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Graphene Oxide Thin Films with Drug Delivery Function

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