Gold Nanotheranostics: Proof-of-Concept or Clinical Tool?

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

Nanoparticles have been making their way in biomedical applications and personalized medicine, allowing for the coupling of diagnostics and therapeutics into a single nanomaterial-nanotheranostics. Gold nanoparticles, in particular, have unique features that make them excellent nanomaterials for theranostics, enabling the integration of targeting, imaging and therapeutics in a single platform, with proven applicability in the management of heterogeneous diseases, such as cancer. In this review, we focus on gold nanoparticle-based theranostics at the lab bench, through pre-clinical and clinical stages. With few products facing clinical trials, much remains to be done to effectively assess the real benefits of nanotheranostics at the clinical level. Hence, we also discuss the efforts currently being made to translate nanotheranostics into the market, as well as their commercial impact.

Original languageEnglish
Pages (from-to)1853-1879
Number of pages27
JournalNanomaterials
Volume5
Issue number4
DOIs
Publication statusPublished - Dec 2015

Keywords

  • nanotheranostics
  • diagnostics
  • targeted therapy
  • cancer
  • gold nanoparticles
  • precision medicine
  • theranostics
  • NEAR-INFRARED LIGHT
  • PEGYLATED LIPOSOMAL DOXORUBICIN
  • IN-VIVO
  • CANCER-CELLS
  • PHOTOTHERMAL THERAPY
  • THERANOSTIC AGENTS
  • DRUG-DELIVERY
  • BREAST-CANCER
  • MULTIFUNCTIONAL NANOPARTICLES
  • BIOMEDICAL APPLICATIONS

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