Gold nanoparticles in molecular diagnostics and molecular therapeutics

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Gold nanoparticles, due to their unique physicochemical properties, are among the most widely used nanoscale-based platforms for molecular diagnostics. The intrinsic chemical stability and apparent lack of toxicity have also prompted for application in therapeutics, e.g., for imaging modalities and as vectorization strategies for molecular modulators, i.e., gene silencing, specific targeting of cellular pathways, etc. Because of their common molecular ground, these approaches have been synergistically coupled together into molecular theranostic systems that allow for radical new in vivo diagnostics modalities with simultaneous tackling of molecular disequilibria leading to disease. Despite this tremendous potential, gold nanoparticle- based systems still have to make their effective translation to the clinics. This chapter focuses on the use of gold nanoparticles for molecular diagnostics and molecular therapeutics and their application in theranostics. Attention is paid to those systems that have moved toward the clinics.

Original languageEnglish
Title of host publicationMetal Nanoparticles in Pharma
PublisherSpringer International Publishing
Pages365-387
Number of pages23
ISBN (Electronic)978-331963790-7
ISBN (Print)978-331963789-1
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Molecular Pathology
Gold
Nanoparticles
Gene Silencing
Therapeutics
Theranostic Nanomedicine

Keywords

  • Molecular diagnostics
  • Molecular therapeutics
  • Nanodiagnostics
  • Nanomedicine
  • Nanotheranostics
  • Targeted delivery

Cite this

Matias, A. S., Carlos, F. F., Pedrosa, P., Fernandes, A. R., & Baptista, P. V. (2017). Gold nanoparticles in molecular diagnostics and molecular therapeutics. In Metal Nanoparticles in Pharma (pp. 365-387). Springer International Publishing. https://doi.org/10.1007/978-3-319-63790-7_16
Matias, Ana S. ; Carlos, Fábio F. ; Pedrosa, P. ; Fernandes, Alexandra R. ; Baptista, Pedro V. / Gold nanoparticles in molecular diagnostics and molecular therapeutics. Metal Nanoparticles in Pharma. Springer International Publishing, 2017. pp. 365-387
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Matias, AS, Carlos, FF, Pedrosa, P, Fernandes, AR & Baptista, PV 2017, Gold nanoparticles in molecular diagnostics and molecular therapeutics. in Metal Nanoparticles in Pharma. Springer International Publishing, pp. 365-387. https://doi.org/10.1007/978-3-319-63790-7_16

Gold nanoparticles in molecular diagnostics and molecular therapeutics. / Matias, Ana S.; Carlos, Fábio F.; Pedrosa, P.; Fernandes, Alexandra R.; Baptista, Pedro V.

Metal Nanoparticles in Pharma. Springer International Publishing, 2017. p. 365-387.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Matias AS, Carlos FF, Pedrosa P, Fernandes AR, Baptista PV. Gold nanoparticles in molecular diagnostics and molecular therapeutics. In Metal Nanoparticles in Pharma. Springer International Publishing. 2017. p. 365-387 https://doi.org/10.1007/978-3-319-63790-7_16