Gold nanoparticles for DNA/RNA-based diagnostics

Ricardo Franco; Pedro Pedrosa; Fábio Ferreira Carlos; Bruno Veigas; Pedro Miguel Ribeiro Viana Baptista

doi:10.1007/978-3-319-15338-4_31

Gold nanoparticles for DNA/RNA-based diagnostics

Ricardo Franco, Pedro Pedrosa, Fábio Ferreira Carlos, Bruno Veigas, Pedro Miguel Ribeiro Viana Baptista

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted development in exploring biomolecular interactions with AuNPscontaining systems, pursuing biomedical applications in diagnostics. Among these applications, AuNPs have been remarkably useful for the development of DNA/RNA detection and characterization systems for diagnostics, including systems suitable for point of need. Here, emphasis will be on available molecular detection schemes of relevant pathogens and their molecular characterization, genomic sequences associated with medical conditions (including cancer), mutation and polymorphism identification, and the quantification of gene expression.

Original language	English
Title of host publication	Handbook of Nanoparticles
Publisher	SPRINGER INTERNATIONAL PUBLISHING AG
Pages	1339-1370
Number of pages	32
ISBN (Electronic)	9783319153384
ISBN (Print)	9783319153377
DOIs	https://doi.org/10.1007/978-3-319-15338-4_31
Publication status	Published - 18 Sep 2015

Keywords

Au-nanobeacons
Au-nanoprobes
LSPR
Nucleic acid
Pathogen
Point of care
SNP

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10.1007/978-3-319-15338-4_31

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AU - Franco, Ricardo

AU - Pedrosa, Pedro

AU - Carlos, Fábio Ferreira

AU - Veigas, Bruno

AU - Baptista, Pedro Miguel Ribeiro Viana

PY - 2015/9/18

Y1 - 2015/9/18

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AB - The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted development in exploring biomolecular interactions with AuNPscontaining systems, pursuing biomedical applications in diagnostics. Among these applications, AuNPs have been remarkably useful for the development of DNA/RNA detection and characterization systems for diagnostics, including systems suitable for point of need. Here, emphasis will be on available molecular detection schemes of relevant pathogens and their molecular characterization, genomic sequences associated with medical conditions (including cancer), mutation and polymorphism identification, and the quantification of gene expression.

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KW - Au-nanoprobes

KW - LSPR

KW - Nucleic acid

KW - Pathogen

KW - Point of care

KW - SNP

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BT - Handbook of Nanoparticles

PB - SPRINGER INTERNATIONAL PUBLISHING AG

ER -

Gold nanoparticles for DNA/RNA-based diagnostics

Abstract

Keywords

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