Gold nanoparticles for DNA/RNA-based diagnostics

Ricardo Franco, Pedro Pedrosa, Fábio Ferreira Carlos, Bruno Veigas, Pedro Miguel Ribeiro Viana Baptista

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted development in exploring biomolecular interactions with AuNPscontaining systems, pursuing biomedical applications in diagnostics. Among these applications, AuNPs have been remarkably useful for the development of DNA/RNA detection and characterization systems for diagnostics, including systems suitable for point of need. Here, emphasis will be on available molecular detection schemes of relevant pathogens and their molecular characterization, genomic sequences associated with medical conditions (including cancer), mutation and polymorphism identification, and the quantification of gene expression.

Original languageEnglish
Title of host publicationHandbook of Nanoparticles
PublisherSPRINGER INTERNATIONAL PUBLISHING AG
Pages1339-1370
Number of pages32
ISBN (Electronic)9783319153384
ISBN (Print)9783319153377
DOIs
Publication statusPublished - 18 Sep 2015

Keywords

  • Au-nanobeacons
  • Au-nanoprobes
  • LSPR
  • Nucleic acid
  • Pathogen
  • Point of care
  • SNP

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    Franco, R., Pedrosa, P., Carlos, F. F., Veigas, B., & Baptista, P. M. R. V. (2015). Gold nanoparticles for DNA/RNA-based diagnostics. In Handbook of Nanoparticles (pp. 1339-1370). SPRINGER INTERNATIONAL PUBLISHING AG. https://doi.org/10.1007/978-3-319-15338-4_31