Gold Nanoparticles as (Bio)Chemical Sensors

Miguel Peixoto de Almeida, Eulália Pereira, Pedro Baptista, Inês Gomes, Sara Figueiredo, Leonor Soares, Ricardo Franco

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


This chapter focuses on several sensing strategies and major recent advances in the use of gold nanoparticles in (bio)sensing of chemical and biological analytes. A brief introduction is presented on relevant properties of gold nanoparticles for sensing, the main types of (bio)chemical sensors, and the main detection techniques, followed by subsections according to sensing methodologies. These include colorimetric sensing and the biobarcode assay, fluorometric-based methods, electric and electrochemical sensing, and, last, more recent and advanced methodologies such as surface plasmon resonance and Raman-based sensors. In closing, relevance is given to advanced methods, featuring extremely high sensitivity and selectivity, down to single-molecule detection. Anisotropic gold nanoparticles have a special role in future developments.

Original languageEnglish
Pages (from-to)529-567
Number of pages39
JournalComprehensive Analytical Chemistry
Publication statusPublished - 2014


  • (Bio)chemical sensor
  • Anisotropic nanoparticles
  • Bioassay
  • DNA
  • Gold nanoparticles
  • Immunoassay


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