Gold Nanoconjugates for miRNA Modulation in Cancer Therapy:  From miRNA Silencing to miRNA Mimics

Diana P. Sousa; João Conde

doi:https://doi.org/10.1021/acsmaterialsau.2c00042

Gold Nanoconjugates for miRNA Modulation in Cancer Therapy: From miRNA Silencing to miRNA Mimics

Diana P. Sousa, João Conde

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

23 Downloads (Pure)

Abstract

Cancer is a major healthcare burden and cause of death worldwide, with an estimated 19.3 million new cancer cases and 10 million cancer deaths globally only in 2020. While several anticancer therapeutics are available to date, many of these still show low treatment efficacy and high off-target effects and adverse reactions. This prompts a serious need to develop novel therapies that can decrease the side effects and increase treatment efficacy. MicroRNAs (miRNAs) can have a role in tumor development and progression, making them important targets for the improvement of anticancer therapies. In this context, gold nanoparticles have been widely studied for different clinical applications due to their biocompatibility and possibility of customization, and gold nanoconjugates targeting miRNAs are being developed for cancer diagnosis and treatment. Here we summarize the research developed so far and how it can contribute to cancer treatment, discuss how it can be improved, and present the current challenges and future perspectives on their design and application.

Original language	English
Pages (from-to)	626-640
Journal	ACS Materials Au
Volume	2
Issue number	6
DOIs	https://doi.org/10.1021/acsmaterialsau.2c00042
Publication status	Published - 13 Aug 2022

Keywords

Cancer
Cancer therapy
Gene therapy
Gold
Nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1021/acsmaterialsau.2c00042

acsmaterialsau.2c00042Final published version, 5.06 MBLicence: CC BY

Cite this

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title = "Gold Nanoconjugates for miRNA Modulation in Cancer Therapy: From miRNA Silencing to miRNA Mimics",

abstract = "Cancer is a major healthcare burden and cause of death worldwide, with an estimated 19.3 million new cancer cases and 10 million cancer deaths globally only in 2020. While several anticancer therapeutics are available to date, many of these still show low treatment efficacy and high off-target effects and adverse reactions. This prompts a serious need to develop novel therapies that can decrease the side effects and increase treatment efficacy. MicroRNAs (miRNAs) can have a role in tumor development and progression, making them important targets for the improvement of anticancer therapies. In this context, gold nanoparticles have been widely studied for different clinical applications due to their biocompatibility and possibility of customization, and gold nanoconjugates targeting miRNAs are being developed for cancer diagnosis and treatment. Here we summarize the research developed so far and how it can contribute to cancer treatment, discuss how it can be improved, and present the current challenges and future perspectives on their design and application.",

keywords = "Cancer, Cancer therapy, Gene therapy, Gold, Nanoparticles",

author = "Sousa, {Diana P.} and Jo{\~a}o Conde",

note = "Funding This work was supported by the FCT PhD Scholarship (2020.06638.BD, Diana P. Sousa) and by the European Research Council Starting Grant ERC-StG-2019-848325 (2019−2024, Jo{\~a}o Conde).",

year = "2022",

month = aug,

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doi = "https://doi.org/10.1021/acsmaterialsau.2c00042",

language = "English",

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pages = "626--640",

journal = "ACS Materials Au",

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TY - JOUR

T1 - Gold Nanoconjugates for miRNA Modulation in Cancer Therapy

T2 - From miRNA Silencing to miRNA Mimics

AU - Sousa, Diana P.

AU - Conde, João

N1 - Funding This work was supported by the FCT PhD Scholarship (2020.06638.BD, Diana P. Sousa) and by the European Research Council Starting Grant ERC-StG-2019-848325 (2019−2024, João Conde).

PY - 2022/8/13

Y1 - 2022/8/13

N2 - Cancer is a major healthcare burden and cause of death worldwide, with an estimated 19.3 million new cancer cases and 10 million cancer deaths globally only in 2020. While several anticancer therapeutics are available to date, many of these still show low treatment efficacy and high off-target effects and adverse reactions. This prompts a serious need to develop novel therapies that can decrease the side effects and increase treatment efficacy. MicroRNAs (miRNAs) can have a role in tumor development and progression, making them important targets for the improvement of anticancer therapies. In this context, gold nanoparticles have been widely studied for different clinical applications due to their biocompatibility and possibility of customization, and gold nanoconjugates targeting miRNAs are being developed for cancer diagnosis and treatment. Here we summarize the research developed so far and how it can contribute to cancer treatment, discuss how it can be improved, and present the current challenges and future perspectives on their design and application.

AB - Cancer is a major healthcare burden and cause of death worldwide, with an estimated 19.3 million new cancer cases and 10 million cancer deaths globally only in 2020. While several anticancer therapeutics are available to date, many of these still show low treatment efficacy and high off-target effects and adverse reactions. This prompts a serious need to develop novel therapies that can decrease the side effects and increase treatment efficacy. MicroRNAs (miRNAs) can have a role in tumor development and progression, making them important targets for the improvement of anticancer therapies. In this context, gold nanoparticles have been widely studied for different clinical applications due to their biocompatibility and possibility of customization, and gold nanoconjugates targeting miRNAs are being developed for cancer diagnosis and treatment. Here we summarize the research developed so far and how it can contribute to cancer treatment, discuss how it can be improved, and present the current challenges and future perspectives on their design and application.

KW - Cancer

KW - Cancer therapy

KW - Gene therapy

KW - Gold

KW - Nanoparticles

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DO - https://doi.org/10.1021/acsmaterialsau.2c00042

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VL - 2

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EP - 640

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JF - ACS Materials Au

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ER -