Glycans in infectious diseases. A molecular recognition perspective

Luca Unione, Ana Gimeno, Pablo Valverde, Ilaria Calloni, Helena Coelho, Stefania Mirabella, Ana Poveda, Ana Ardá, Jesús Jiménez-Barbero

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Background: From the simplest bacteria to the highest complex mammals, including humans, every single cell is covered by a dense coat of glycans. Glycans are involved in almost every biological process that takes place in our body, playing a central role in the communication between cells and their environment. Glycans are also involved in infectious diseases, which arise from the specific interaction between glycans of the pathogen cell coat and specific receptors on the host cell or vice versa. Objective: The understanding of the mechanisms governing these specific carbohydrateprotein interactions, at atomic and molecular levels, is crucial to develop new drugs able to block the infection and to avoid the disease. Methods: Recent advances in biophysical techniques allow for a complete picture of the hostpathogen infection event, unveiling the key aspects of the molecular interaction and, thus, providing an opportunity to interfere with it. Conclusion: In this general review, we discuss some recent contributions, providing a summary of what we consider the most innovative and inspiring research lines to the field.

Original languageEnglish
Pages (from-to)4057-4080
Number of pages24
JournalCurrent Medicinal Chemistry
Volume24
Issue number36
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

Molecular recognition
Communicable Diseases
Polysaccharides
Biological Phenomena
Glycocalyx
Mammals
Molecular interactions
Pathogens
Infection
Cell Communication
Bacteria
Communication
Research
Pharmaceutical Preparations

Keywords

  • Bacterial infection
  • Glycans
  • Lectin
  • Molecular recognition
  • NMR
  • Viral infection
  • X-ray

Cite this

Unione, L., Gimeno, A., Valverde, P., Calloni, I., Coelho, H., Mirabella, S., ... Jiménez-Barbero, J. (2017). Glycans in infectious diseases. A molecular recognition perspective. Current Medicinal Chemistry, 24(36), 4057-4080. https://doi.org/10.2174/0929867324666170217093702
Unione, Luca ; Gimeno, Ana ; Valverde, Pablo ; Calloni, Ilaria ; Coelho, Helena ; Mirabella, Stefania ; Poveda, Ana ; Ardá, Ana ; Jiménez-Barbero, Jesús. / Glycans in infectious diseases. A molecular recognition perspective. In: Current Medicinal Chemistry. 2017 ; Vol. 24, No. 36. pp. 4057-4080.
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Unione, L, Gimeno, A, Valverde, P, Calloni, I, Coelho, H, Mirabella, S, Poveda, A, Ardá, A & Jiménez-Barbero, J 2017, 'Glycans in infectious diseases. A molecular recognition perspective', Current Medicinal Chemistry, vol. 24, no. 36, pp. 4057-4080. https://doi.org/10.2174/0929867324666170217093702

Glycans in infectious diseases. A molecular recognition perspective. / Unione, Luca; Gimeno, Ana; Valverde, Pablo; Calloni, Ilaria; Coelho, Helena ; Mirabella, Stefania; Poveda, Ana; Ardá, Ana; Jiménez-Barbero, Jesús.

In: Current Medicinal Chemistry, Vol. 24, No. 36, 01.11.2017, p. 4057-4080.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Glycans in infectious diseases. A molecular recognition perspective

AU - Unione, Luca

AU - Gimeno, Ana

AU - Valverde, Pablo

AU - Calloni, Ilaria

AU - Coelho, Helena

AU - Mirabella, Stefania

AU - Poveda, Ana

AU - Ardá, Ana

AU - Jiménez-Barbero, Jesús

N1 - We thank financial support from the Marie Curie Initial Training Networks TOLLerant and GlycoVAX (EU), grant CTQ2015-64597-C2-1-P of MINECO (Spain), a FPU fellowship to P. V. and the Juan de la Cierva and Ramon y Cajal contracts to A. G. and A. A., respectively. We also thank CIC bioGUNE for continuous funding.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background: From the simplest bacteria to the highest complex mammals, including humans, every single cell is covered by a dense coat of glycans. Glycans are involved in almost every biological process that takes place in our body, playing a central role in the communication between cells and their environment. Glycans are also involved in infectious diseases, which arise from the specific interaction between glycans of the pathogen cell coat and specific receptors on the host cell or vice versa. Objective: The understanding of the mechanisms governing these specific carbohydrateprotein interactions, at atomic and molecular levels, is crucial to develop new drugs able to block the infection and to avoid the disease. Methods: Recent advances in biophysical techniques allow for a complete picture of the hostpathogen infection event, unveiling the key aspects of the molecular interaction and, thus, providing an opportunity to interfere with it. Conclusion: In this general review, we discuss some recent contributions, providing a summary of what we consider the most innovative and inspiring research lines to the field.

AB - Background: From the simplest bacteria to the highest complex mammals, including humans, every single cell is covered by a dense coat of glycans. Glycans are involved in almost every biological process that takes place in our body, playing a central role in the communication between cells and their environment. Glycans are also involved in infectious diseases, which arise from the specific interaction between glycans of the pathogen cell coat and specific receptors on the host cell or vice versa. Objective: The understanding of the mechanisms governing these specific carbohydrateprotein interactions, at atomic and molecular levels, is crucial to develop new drugs able to block the infection and to avoid the disease. Methods: Recent advances in biophysical techniques allow for a complete picture of the hostpathogen infection event, unveiling the key aspects of the molecular interaction and, thus, providing an opportunity to interfere with it. Conclusion: In this general review, we discuss some recent contributions, providing a summary of what we consider the most innovative and inspiring research lines to the field.

KW - Bacterial infection

KW - Glycans

KW - Lectin

KW - Molecular recognition

KW - NMR

KW - Viral infection

KW - X-ray

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DO - 10.2174/0929867324666170217093702

M3 - Review article

VL - 24

SP - 4057

EP - 4080

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

SN - 0929-8673

IS - 36

ER -