Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population

António Moreira, Gisela Martins, M. João Monteiro, Margarida Alves, Joana Dias, J. Duro Da Costa, M. José Melo, Dina Matias, Agostinho Costa, Margarida Cristóvão, José Rueff, Caroline Monteiro

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Epidemiological studies have led to the suggestion that a genetic basis may exist in the individual variation in predisposition to cancer. Interindividual differences in human toxicological response to carcinogenic exposure have been attributed to heritable polymorphisms in metabolism, namely glutathione S-transferases (GSTs) coding for enzymes that are known to be detoxifiers of carcinogens. Within the human GST mu class, there is a specific isozyme that is frequently lacking. To check whether or not this association exists in the Portuguese population with lung cancer, we used polymerase chain reaction (PCR)-based genotyping to examine GSTM1 polymorphism (nulled and non-nulled) in 84 individuals as a control healthy population and a group of 98 lung cancer patients. In this study we were able to find a frequency of the GSTM1 phenotype among our healthy control subjects consistent with earlier genotyping studies in other Caucasoid populations. For the group of individuals with lung cancer as a whole, or in subsets of histological subtypes, our data for the Portuguese population did not show a positive correlation between the null allele and this neoplasm. In contrast, we found a slight increase in the frequency of the wild-type allele in our lung cancer group.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalTeratogenesis Carcinogenesis And Mutagenesis
Volume16
Issue number5 PART 2
Publication statusPublished - 1 Dec 1996

Fingerprint

Glutathione Transferase
Polymorphism
Lung Neoplasms
Polymerase chain reaction
Metabolism
Carcinogens
Population
Isoenzymes
Enzymes
Population Groups
Gene Frequency
Toxicology
Epidemiologic Studies
Neoplasms
Healthy Volunteers
Alleles
Phenotype
Polymerase Chain Reaction

Keywords

  • Cancer epidemiology
  • Cancer susceptibility
  • Glutathione S-transferase
  • GSTM1 polymorphism
  • Lung cancer
  • Null allele
  • Portuguese population

Cite this

Moreira, A., Martins, G., Monteiro, M. J., Alves, M., Dias, J., Duro Da Costa, J., ... Monteiro, C. (1996). Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population. Teratogenesis Carcinogenesis And Mutagenesis, 16(5 PART 2), 269-274.
Moreira, António ; Martins, Gisela ; Monteiro, M. João ; Alves, Margarida ; Dias, Joana ; Duro Da Costa, J. ; Melo, M. José ; Matias, Dina ; Costa, Agostinho ; Cristóvão, Margarida ; Rueff, José ; Monteiro, Caroline. / Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population. In: Teratogenesis Carcinogenesis And Mutagenesis. 1996 ; Vol. 16, No. 5 PART 2. pp. 269-274.
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Moreira, A, Martins, G, Monteiro, MJ, Alves, M, Dias, J, Duro Da Costa, J, Melo, MJ, Matias, D, Costa, A, Cristóvão, M, Rueff, J & Monteiro, C 1996, 'Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population', Teratogenesis Carcinogenesis And Mutagenesis, vol. 16, no. 5 PART 2, pp. 269-274.

Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population. / Moreira, António; Martins, Gisela; Monteiro, M. João; Alves, Margarida; Dias, Joana; Duro Da Costa, J.; Melo, M. José; Matias, Dina; Costa, Agostinho; Cristóvão, Margarida; Rueff, José; Monteiro, Caroline.

In: Teratogenesis Carcinogenesis And Mutagenesis, Vol. 16, No. 5 PART 2, 01.12.1996, p. 269-274.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population

AU - Moreira, António

AU - Martins, Gisela

AU - Monteiro, M. João

AU - Alves, Margarida

AU - Dias, Joana

AU - Duro Da Costa, J.

AU - Melo, M. José

AU - Matias, Dina

AU - Costa, Agostinho

AU - Cristóvão, Margarida

AU - Rueff, José

AU - Monteiro, Caroline

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Epidemiological studies have led to the suggestion that a genetic basis may exist in the individual variation in predisposition to cancer. Interindividual differences in human toxicological response to carcinogenic exposure have been attributed to heritable polymorphisms in metabolism, namely glutathione S-transferases (GSTs) coding for enzymes that are known to be detoxifiers of carcinogens. Within the human GST mu class, there is a specific isozyme that is frequently lacking. To check whether or not this association exists in the Portuguese population with lung cancer, we used polymerase chain reaction (PCR)-based genotyping to examine GSTM1 polymorphism (nulled and non-nulled) in 84 individuals as a control healthy population and a group of 98 lung cancer patients. In this study we were able to find a frequency of the GSTM1 phenotype among our healthy control subjects consistent with earlier genotyping studies in other Caucasoid populations. For the group of individuals with lung cancer as a whole, or in subsets of histological subtypes, our data for the Portuguese population did not show a positive correlation between the null allele and this neoplasm. In contrast, we found a slight increase in the frequency of the wild-type allele in our lung cancer group.

AB - Epidemiological studies have led to the suggestion that a genetic basis may exist in the individual variation in predisposition to cancer. Interindividual differences in human toxicological response to carcinogenic exposure have been attributed to heritable polymorphisms in metabolism, namely glutathione S-transferases (GSTs) coding for enzymes that are known to be detoxifiers of carcinogens. Within the human GST mu class, there is a specific isozyme that is frequently lacking. To check whether or not this association exists in the Portuguese population with lung cancer, we used polymerase chain reaction (PCR)-based genotyping to examine GSTM1 polymorphism (nulled and non-nulled) in 84 individuals as a control healthy population and a group of 98 lung cancer patients. In this study we were able to find a frequency of the GSTM1 phenotype among our healthy control subjects consistent with earlier genotyping studies in other Caucasoid populations. For the group of individuals with lung cancer as a whole, or in subsets of histological subtypes, our data for the Portuguese population did not show a positive correlation between the null allele and this neoplasm. In contrast, we found a slight increase in the frequency of the wild-type allele in our lung cancer group.

KW - Cancer epidemiology

KW - Cancer susceptibility

KW - Glutathione S-transferase

KW - GSTM1 polymorphism

KW - Lung cancer

KW - Null allele

KW - Portuguese population

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M3 - Article

VL - 16

SP - 269

EP - 274

JO - Teratogenesis Carcinogenesis And Mutagenesis

JF - Teratogenesis Carcinogenesis And Mutagenesis

SN - 0270-3211

IS - 5 PART 2

ER -

Moreira A, Martins G, Monteiro MJ, Alves M, Dias J, Duro Da Costa J et al. Glutathione S-transferase Mu polymorphism and susceptibility to lung cancer in the portuguese population. Teratogenesis Carcinogenesis And Mutagenesis. 1996 Dec 1;16(5 PART 2):269-274.