Glomerular C3b receptor loss in renal allografts.

F. Nolasco, B. Hartley, R. Reuben, K. Welsh

Research output: Contribution to journalArticle

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Abstract

There is almost no data from the glomeruli of allografted kidneys with respect to changes in the CR-1 (C3b) receptor expressed on glomerular podocytes. We studied 22 renal graft biopsies from rejecting and stable allografts, using a panel of monoclonal antibodies. We found that the CR-1 expression was decreased in a focal and segmental fashion in some biopsies, particularly in rejecting kidneys. These changes correlated with the intensity of glomerular mononuclear cell infiltration, but in contrast no correlation was seen with peripheral capillary wall deposition of complement (C3). Thus, some active process is occurring in the glomeruli of rejecting grafts which affects the expression of the CR-1 receptor.

Original languageEnglish
Pages (from-to)1015-1020
Number of pages6
JournalProceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
Volume21
Publication statusPublished - 1 Jan 1985

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