Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Ola B. Brynildsrud, Caitlin S. Pepperell, Philip Suffys, Louis Grandjean, Johana Monteserin, Nadia Debech, Jon Bohlin, Kristian Alfsnes, John O.H. Pettersson, Ingerid Kirkeleite, Fatima Fandinho, Marcia Aparecida da Silva, Joao Perdigao, Isabel Portugal, Miguel Viveiros, Taane Clark, Maxine Caws, Sarah Dunstan, Phan Vuong Khac Thai, Beatriz Lopez & 10 others Viviana Ritacco, Andrew Kitchen, Tyler S. Brown, Dick van Soolingen, Mary B. O'Neill, Kathryn E. Holt, Edward J. Feil, Barun Mathema, Francois Balloux, Vegard Eldholm

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

Original languageEnglish
Article numbereaat5869
Pages (from-to)eaat5869-eaat5880
Number of pages11
JournalScience Advances
Volume4
Issue number10
DOIs
Publication statusPublished - 17 Oct 2018

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Mycobacterium tuberculosis
Metagenomics
Multidrug-Resistant Tuberculosis
Mutation
Tuberculosis
Genome
Anti-Bacterial Agents

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Brynildsrud, O. B., Pepperell, C. S., Suffys, P., Grandjean, L., Monteserin, J., Debech, N., ... Eldholm, V. (2018). Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Science Advances, 4(10), eaat5869-eaat5880. [eaat5869]. https://doi.org/10.1126/sciadv.aat5869
Brynildsrud, Ola B. ; Pepperell, Caitlin S. ; Suffys, Philip ; Grandjean, Louis ; Monteserin, Johana ; Debech, Nadia ; Bohlin, Jon ; Alfsnes, Kristian ; Pettersson, John O.H. ; Kirkeleite, Ingerid ; Fandinho, Fatima ; da Silva, Marcia Aparecida ; Perdigao, Joao ; Portugal, Isabel ; Viveiros, Miguel ; Clark, Taane ; Caws, Maxine ; Dunstan, Sarah ; Thai, Phan Vuong Khac ; Lopez, Beatriz ; Ritacco, Viviana ; Kitchen, Andrew ; Brown, Tyler S. ; van Soolingen, Dick ; O'Neill, Mary B. ; Holt, Kathryn E. ; Feil, Edward J. ; Mathema, Barun ; Balloux, Francois ; Eldholm, Vegard. / Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. In: Science Advances. 2018 ; Vol. 4, No. 10. pp. eaat5869-eaat5880.
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abstract = "On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.",
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Brynildsrud, OB, Pepperell, CS, Suffys, P, Grandjean, L, Monteserin, J, Debech, N, Bohlin, J, Alfsnes, K, Pettersson, JOH, Kirkeleite, I, Fandinho, F, da Silva, MA, Perdigao, J, Portugal, I, Viveiros, M, Clark, T, Caws, M, Dunstan, S, Thai, PVK, Lopez, B, Ritacco, V, Kitchen, A, Brown, TS, van Soolingen, D, O'Neill, MB, Holt, KE, Feil, EJ, Mathema, B, Balloux, F & Eldholm, V 2018, 'Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation', Science Advances, vol. 4, no. 10, eaat5869, pp. eaat5869-eaat5880. https://doi.org/10.1126/sciadv.aat5869

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. / Brynildsrud, Ola B.; Pepperell, Caitlin S.; Suffys, Philip; Grandjean, Louis; Monteserin, Johana; Debech, Nadia; Bohlin, Jon; Alfsnes, Kristian; Pettersson, John O.H.; Kirkeleite, Ingerid; Fandinho, Fatima; da Silva, Marcia Aparecida; Perdigao, Joao; Portugal, Isabel; Viveiros, Miguel; Clark, Taane; Caws, Maxine; Dunstan, Sarah; Thai, Phan Vuong Khac; Lopez, Beatriz; Ritacco, Viviana; Kitchen, Andrew; Brown, Tyler S.; van Soolingen, Dick; O'Neill, Mary B.; Holt, Kathryn E.; Feil, Edward J.; Mathema, Barun; Balloux, Francois; Eldholm, Vegard.

In: Science Advances, Vol. 4, No. 10, eaat5869, 17.10.2018, p. eaat5869-eaat5880.

Research output: Contribution to journalArticle

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T1 - Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

AU - Brynildsrud, Ola B.

AU - Pepperell, Caitlin S.

AU - Suffys, Philip

AU - Grandjean, Louis

AU - Monteserin, Johana

AU - Debech, Nadia

AU - Bohlin, Jon

AU - Alfsnes, Kristian

AU - Pettersson, John O.H.

AU - Kirkeleite, Ingerid

AU - Fandinho, Fatima

AU - da Silva, Marcia Aparecida

AU - Perdigao, Joao

AU - Portugal, Isabel

AU - Viveiros, Miguel

AU - Clark, Taane

AU - Caws, Maxine

AU - Dunstan, Sarah

AU - Thai, Phan Vuong Khac

AU - Lopez, Beatriz

AU - Ritacco, Viviana

AU - Kitchen, Andrew

AU - Brown, Tyler S.

AU - van Soolingen, Dick

AU - O'Neill, Mary B.

AU - Holt, Kathryn E.

AU - Feil, Edward J.

AU - Mathema, Barun

AU - Balloux, Francois

AU - Eldholm, Vegard

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AB - On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

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VL - 4

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JO - Science Advances

JF - Science Advances

SN - 2375-2548

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Brynildsrud OB, Pepperell CS, Suffys P, Grandjean L, Monteserin J, Debech N et al. Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Science Advances. 2018 Oct 17;4(10):eaat5869-eaat5880. eaat5869. https://doi.org/10.1126/sciadv.aat5869