Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Ola B. Brynildsrud; Caitlin S. Pepperell; Philip Suffys; Louis Grandjean; Johana Monteserin; Nadia Debech; Jon Bohlin; Kristian Alfsnes; John O.H. Pettersson; Ingerid Kirkeleite; Fatima Fandinho; Marcia Aparecida da Silva; Joao Perdigao; Isabel Portugal; Miguel Viveiros; Taane Clark; Maxine Caws; Sarah Dunstan; Phan Vuong Khac Thai; Beatriz Lopez; Viviana Ritacco; Andrew Kitchen; Tyler S. Brown; Dick van Soolingen; Mary B. O'Neill; Kathryn E. Holt; Edward J. Feil; Barun Mathema; Francois Balloux; Vegard Eldholm

doi:10.1126/sciadv.aat5869

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Ola B. Brynildsrud, Caitlin S. Pepperell, Philip Suffys, Louis Grandjean, Johana Monteserin, Nadia Debech, Jon Bohlin, Kristian Alfsnes, John O.H. Pettersson, Ingerid Kirkeleite, Fatima Fandinho, Marcia Aparecida da Silva, Joao Perdigao, Isabel Portugal, Miguel Viveiros, Taane Clark, Maxine Caws, Sarah Dunstan, Phan Vuong Khac Thai, Beatriz LopezViviana Ritacco, Andrew Kitchen, Tyler S. Brown, Dick van Soolingen, Mary B. O'Neill, Kathryn E. Holt, Edward J. Feil, Barun Mathema, Francois Balloux, Vegard Eldholm

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Abstract

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

Original language	English
Article number	eaat5869
Pages (from-to)	eaat5869
Number of pages	11
Journal	Science Advances
Volume	4
Issue number	10
DOIs	https://doi.org/10.1126/sciadv.aat5869
Publication status	Published - 17 Oct 2018

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Brynildsrud, O. B., Pepperell, C. S., Suffys, P., Grandjean, L., Monteserin, J., Debech, N., Bohlin, J., Alfsnes, K., Pettersson, J. O. H., Kirkeleite, I., Fandinho, F., da Silva, M. A., Perdigao, J., Portugal, I., Viveiros, M., Clark, T., Caws, M., Dunstan, S., Thai, P. V. K., ... Eldholm, V. (2018). Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Science Advances, 4(10), eaat5869. Article eaat5869. https://doi.org/10.1126/sciadv.aat5869

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title = "Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation",

abstract = "On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.",

author = "Brynildsrud, {Ola B.} and Pepperell, {Caitlin S.} and Philip Suffys and Louis Grandjean and Johana Monteserin and Nadia Debech and Jon Bohlin and Kristian Alfsnes and Pettersson, {John O.H.} and Ingerid Kirkeleite and Fatima Fandinho and {da Silva}, {Marcia Aparecida} and Joao Perdigao and Isabel Portugal and Miguel Viveiros and Taane Clark and Maxine Caws and Sarah Dunstan and Thai, {Phan Vuong Khac} and Beatriz Lopez and Viviana Ritacco and Andrew Kitchen and Brown, {Tyler S.} and {van Soolingen}, Dick and O'Neill, {Mary B.} and Holt, {Kathryn E.} and Feil, {Edward J.} and Barun Mathema and Francois Balloux and Vegard Eldholm",

year = "2018",

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Brynildsrud, OB, Pepperell, CS, Suffys, P, Grandjean, L, Monteserin, J, Debech, N, Bohlin, J, Alfsnes, K, Pettersson, JOH, Kirkeleite, I, Fandinho, F, da Silva, MA, Perdigao, J, Portugal, I, Viveiros, M, Clark, T, Caws, M, Dunstan, S, Thai, PVK, Lopez, B, Ritacco, V, Kitchen, A, Brown, TS, van Soolingen, D, O'Neill, MB, Holt, KE, Feil, EJ, Mathema, B, Balloux, F & Eldholm, V 2018, 'Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation', Science Advances, vol. 4, no. 10, eaat5869, pp. eaat5869. https://doi.org/10.1126/sciadv.aat5869

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T1 - Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

AU - Brynildsrud, Ola B.

AU - Pepperell, Caitlin S.

AU - Suffys, Philip

AU - Grandjean, Louis

AU - Monteserin, Johana

AU - Debech, Nadia

AU - Bohlin, Jon

AU - Alfsnes, Kristian

AU - Pettersson, John O.H.

AU - Kirkeleite, Ingerid

AU - Fandinho, Fatima

AU - da Silva, Marcia Aparecida

AU - Perdigao, Joao

AU - Portugal, Isabel

AU - Viveiros, Miguel

AU - Clark, Taane

AU - Caws, Maxine

AU - Dunstan, Sarah

AU - Thai, Phan Vuong Khac

AU - Lopez, Beatriz

AU - Ritacco, Viviana

AU - Kitchen, Andrew

AU - Brown, Tyler S.

AU - van Soolingen, Dick

AU - O'Neill, Mary B.

AU - Holt, Kathryn E.

AU - Feil, Edward J.

AU - Mathema, Barun

AU - Balloux, Francois

AU - Eldholm, Vegard

PY - 2018/10/17

Y1 - 2018/10/17

N2 - On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

AB - On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

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AN - SCOPUS:85055073936

SN - 2375-2548

VL - 4

SP - eaat5869

JO - Science Advances

JF - Science Advances

IS - 10

M1 - eaat5869

ER -

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

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