Geraniol restores antibiotic activities against multidrug-resistant isolates from Gram-Negative species

Leonard Amaral, Lorenzi, Vannina, Muselli, Alain, Bernardini, Antoine François, Berti, Liliane, Jean-Marie Pagès, Jean Michel Bolla

Research output: Contribution to journalArticlepeer-review

153 Citations (Scopus)

Abstract

The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol.
Original languageEnglish
Pages (from-to)2209-2211
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
VolumeVol. 53
Issue numbern.º 5
DOIs
Publication statusPublished - May 2009

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