@article{502c3414cecc4ed7ab24c3affb29a2d9,
title = "Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospital in Portugal",
abstract = "Portugal has one of the highest tuberculosis notification rates of the European Union with Lisbon Health Region having an incidence rate well above the national average. The present study analyses the transmission, drug susceptibility and characteristics of a study population from a Central Lisbon's Hospital. One hundred and thirty-two Mycobacterium tuberculosis clinical isolates were previously tested for drug susceptibility to first-line drugs. The multidrug (MDR) resistance rate was found to be 3.0%, while 13.6% of the isolates were resistant to one or more first-line drugs. HIV serology was available for 98 patients, 26 (26.5%) were positive. Genotyping was performed by MIRU-VNTR and 53 (40,2%) out of the 132 isolates were found to be distributed through 17 MIRU-VNTR clusters of two or more isolates. Lisboa strains accounted for 25.8% of all strains. We conclude that transmission of resistant and susceptible Mycobacterium tuberculosis strains is occurring, with special concern for Lisboa strains.",
keywords = "multidrug resistance, tuberculosis, FRAGMENT-LENGTH-POLYMORPHISM, COMPLEX, INSIGHTS, GENOMIC DELETIONS, MIRUMULTIDRUG-RESISTANT TUBERCULOSIS, TRANSMISSION, MUTATIONS, MOLECULAR EPIDEMIOLOGY, STRAINS, Lisboa family, LINEAGE",
author = "Martins, {Laura Maria Louren{\c c}o Brum da Cruz}",
note = "Rev. Port. Pneumol. Perdigao, Joao Milho, Catarina Carrilho, Lurdes Brum, Laura Portugal, IsabelFundacao para a Ciencia e Tecnologia [POCTI/ESP/42941/2001] This work was supported by Fundacao para a Ciencia e Tecnologia (FCT grant POCTI/ESP/42941/2001). The authors wish to thank to the working group participating in the VigLab surveillance system for data collection and processing. The authors are also. grateful to the personnel from the Sec do de Micobacterias do Servico de Patologia Clinica do Hospital Pulido Valente and Unidade de Micobacterias do Departamento de Doencas Infecciosas do Instituto Nacional de Saude Dr. Mcardo Jorge, whose high quality of service and cooperation have made this work possible. 27 SOC PORTUGUESA PNEUMOLOGIA LISBOA 494WA",
year = "2009",
month = jan,
day = "1",
language = "Unknown",
volume = "15",
pages = "761--769",
journal = "Revista Portuguesa de Pneumologia",
issn = "0873-2159",
publisher = "Elsevier Doyma",
number = "5",
}
