Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa

R. Parreira; A. Esteves; C. Santos; J Piedade; T. Venenno; W. F. Canas-Ferreira

doi:10.1089/08892220050117069

Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa

R. Parreira, A. Esteves, C. Santos, J Piedade, T. Venenno, W. F. Canas-Ferreira

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositive individuals from Bissau (Guinea-Bissau). The estimated values of genetic divergence between individuals were higher than those calculated from sequence information collected in a single individual. We have also found that the sequences surrounding the V3 loop contribute significantly to the overall genetic diversity of the C2V3 region of HIV-2 gp105, while the V3 loop itself seems to be rather conserved. Phylogenetic analysis demonstrated that all the individuals enrolled in this study were infected with HIV-2 subtype A viruses.

Original language	English
Pages (from-to)	1307-1312
Number of pages	6
Journal	AIDS Research and Human Retroviruses
Volume	16
Issue number	13
DOIs	https://doi.org/10.1089/08892220050117069
Publication status	Published - 1 Sept 2000

Keywords

Priority journal
Vaccination
Article
Calculation
Cytotoxicity
Data analysis
DNA sequence
Genetic variability
Genome
Human
Human immunodeficiency virus 2
Mononuclear cell
Phylogeny
Polymerase chain reaction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/08892220050117069

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title = "Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa",

abstract = "The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositive individuals from Bissau (Guinea-Bissau). The estimated values of genetic divergence between individuals were higher than those calculated from sequence information collected in a single individual. We have also found that the sequences surrounding the V3 loop contribute significantly to the overall genetic diversity of the C2V3 region of HIV-2 gp105, while the V3 loop itself seems to be rather conserved. Phylogenetic analysis demonstrated that all the individuals enrolled in this study were infected with HIV-2 subtype A viruses.",

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AU - Parreira, R.

AU - Esteves, A.

AU - Santos, C.

AU - Piedade, J

AU - Venenno, T.

AU - Canas-Ferreira, W. F.

PY - 2000/9/1

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AB - The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositive individuals from Bissau (Guinea-Bissau). The estimated values of genetic divergence between individuals were higher than those calculated from sequence information collected in a single individual. We have also found that the sequences surrounding the V3 loop contribute significantly to the overall genetic diversity of the C2V3 region of HIV-2 gp105, while the V3 loop itself seems to be rather conserved. Phylogenetic analysis demonstrated that all the individuals enrolled in this study were infected with HIV-2 subtype A viruses.

KW - Priority journal

KW - Vaccination

KW - Article

KW - Calculation

KW - Cytotoxicity

KW - Data analysis

KW - DNA sequence

KW - Genetic variability

KW - Genome

KW - Human

KW - Human immunodeficiency virus 2

KW - Mononuclear cell

KW - Phylogeny

KW - Polymerase chain reaction

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ER -

Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa

Abstract

Keywords

UN SDGs

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