Genetic variability of human immunodeficiency virus type 2 C2V3 region within and between individuals from Bissau, Guinea-Bissau, West Africa

R. Parreira, A. Esteves, C. Santos, J Piedade, T. Venenno, W. F. Canas-Ferreira

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The V3 loop of both HIV-1 and HIV-2 is characterized by a high degree of genetic variation. To investigate the spectrum of HIV-2 variability in nature we have focused on the C2V3 region of Env and analyzed 108 viral sequences obtained from uncultured peripheral blood mononuclear cells obtained from 16 HIV-2-seropositive individuals from Bissau (Guinea-Bissau). The estimated values of genetic divergence between individuals were higher than those calculated from sequence information collected in a single individual. We have also found that the sequences surrounding the V3 loop contribute significantly to the overall genetic diversity of the C2V3 region of HIV-2 gp105, while the V3 loop itself seems to be rather conserved. Phylogenetic analysis demonstrated that all the individuals enrolled in this study were infected with HIV-2 subtype A viruses.

Original languageEnglish
Pages (from-to)1307-1312
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume16
Issue number13
DOIs
Publication statusPublished - 1 Sep 2000

Keywords

  • Priority journal
  • Vaccination
  • Article
  • Calculation
  • Cytotoxicity
  • Data analysis
  • DNA sequence
  • Genetic variability
  • Genome
  • Human
  • Human immunodeficiency virus 2
  • Mononuclear cell
  • Phylogeny
  • Polymerase chain reaction

UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-Being

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